Article Sidebar

PDF
Date Published: 20/07/2021
Abstract Views: 376
Views PDF: 187
DOI: https://doi.org/10.51298/vmj.v501i1.462
Issue
Vol. 501 No. 1 (2021)
Section
Các bài báo
How to Cite
Văn Thuấn, T. ., Văn Khiêm, N. ., Thị Thanh Hương, T. ., Mạnh Tuấn, V. ., & Tiến Quang, N. . (2021). EXAMINES THE SEMI-CHRONIC TOXICITIES OF FUCOLEN ON EXPERIMENTAL ANIMALS. Vietnam Medical Journal, 501(1). https://doi.org/10.51298/vmj.v501i1.462

EXAMINES THE SEMI-CHRONIC TOXICITIES OF FUCOLEN ON EXPERIMENTAL ANIMALS

Trần Văn Thuấn, Nguyễn Văn Khiêm, Trần Thị Thanh Hương, Vũ Mạnh Tuấn, Nguyễn Tiến Quang

Main Article Content

Abstract

Objective: To examines the semi-chronic toxicities of Fucolen on experimental animals. Subject and Method: semi-chronic toxicities of the Fucolen were evaluated on 30 Wistar mices on hematopoietic function. Results: after using Fucolen 4 weeks, 8 weeks and 12 weeks, the change of AST, ALT, creatinin in blood no different significants compare to control mice group (p>0,05). There were also  no changes in invitro of liver and kidney tisues. Conclusion: Fucolen is not toxic for mice and mice liver and kidney function.

Article Details

Keywords

Semi-toxicities, liver and kidney function, Fucolen

References

1. Cuong H.D., Thuy T.T.T., Huong T.T., và cộng sự. Structure and hypolipidaemic activity of fucoidan extracted from brown seaweed Sargassum henslowianum. Nat. Prod. Res. 2015; 29:411–415.
2. Malve H. Exploring the ocean for new drug developments: Marine pharmacology. J. Pharm. Bioallied Sci. 2016; 8:83–91.
3. Kinghorn A.D., Chin Y.W., Swanson S.M. Discovery of natural product anticancer agents from biodiverse organisms. Curr. Opin. Drug Discov. Dev. 2009;12: 189–196.
4. Sanjeewa K.K.A., Kim E.A., Son K.T., và cộng sự. Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds: A review. J. Photochem. Photobiol. B-Biol. 2016; 162:100–105.
5. Cunha L., Grenha A. Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications. Mar. Drugs. 2016; 14:42.
6. Sanjeewa K.K.A., Kim E.A., Son K. T. Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds: A review. J. Photochem. Photobiol. B-Biol. 2016; 162:100–105.
7. Bộ Y tế. Quy chế Đánh giá tính an toàn và hiệu lực thuốc Cổ truyền. Quyết định số 371/BYT-QĐ ngày 12/3/1996. 1996.