NGHIÊN CỨU VAI TRÒ CAGPAI CỦA HELICOBACTER PYLORI Ở BỆNH NHÂN UNG THƯ DẠ DÀY

Abstract

Background: Many studies have found that the intactness of H. pylori's cag pathogenicity island (cagPAI) is associated with gastric cancer (GC) risk, however the results are inconsistent. Aim: This research aims to investigate the relationship between H. pylori’s cagPAI intactness and the risk of GC in Vietnam. Subjects and methods: A cross-sectional study of 179 patients with H. pylori infection, in which 89 patients with gastric cancer and 90 patients with chronic gastritis (CG). Diagnosis of GC and CG is based on histopathology. CagPAI status was determined through the present or absent of three genes cagA, cagE, cagT by realtime-PCR technique. Results: 100% of H. pylori strains carried cagPAI gene, in which the rate of H. pylori carrying the intact cagPAI was 70.4%. The GC group had a higher rate of intact cagPAI than the CG group (79.8% vs 61.1%), the difference was statistically significant (OR = 2.5; p < 0.01). In gastric cancer patients: There was no difference in the prevalence of H. pylori carrying the cagPAI gene by age group, gender, macroscopic characteristics on endoscopy (according to Borrmann classification) and on histopathology (according to the Borrmann classification). Lauren's classification). Conclusion: The intact cagPAI of H. pylori is associated with the risk of gastric cancer in Vietnam.