MỐI LIÊN QUAN GIỮA MỨC ĐỘ XƠ HOÁ GAN VỚI KIỂU GEN HBV Ở BỆNH NHÂN UNG THƯ BIỂU MÔ TẾ BÀO GAN

Abstract

Background: Prior studies have shown patients with HBV infection of genotype C have a higher risk of liver fibrosis and developing cirrhosis and liver cancer than patients with HBV infection of genotype B. Aim: Evaluation of the relationship between the levels of hepatic fibrosis with HBV genotypes in HBV-related HCC patients. Patients and methods: Descriptive cross-sectional study of 107 HCC patients were infected with hepatitis B virus genotypes B and C, which were histologically diagnosed following hepatic resection at Cho Ray hospital from October 2018 to April 2019. The degree of liver fibrosis was graded according to Ishak's Modified Histologic Activity Index (HAI). Results: The average age of patients in the study was 51.4 ± 11.4 years old. The ratio of men to women is 94 to 13. The proportions of HCC patients with and without cirrhosis were 35.5% and 64.5%. Cirrhosis was more common in HCC patients with HBV infection genotype C than with genotype B (80% and 53.2%, p=0.005). Patients with HBeAg-positive comorbidities will have a lower mean age (45.96 ± 10.7 years old and 54.66 ± 11.37 years old, p=0.002) but a greater risk of cirrhosis (87.1% and 55.3%, p=0.002). Conclusions: HCC patients infected with HBV genotype C had more aggressive hepatic fibrosis than genotype B patients. HBeAg-positive patients have a higher rate of cirrhosis, but the mean age is lower than that of HBeAg-negative patients.