NHẬN XÉT NỒNG ĐỘ PROGESTERONE VỚI TỶ LỆ THAI LÂM SÀNG TRONG CHUYỂN PHÔI ĐÔNG LẠNH

Abstract

Objectives: To review progesterone levels prior to embryo transfer with clinical pregnancy rates in day 5 frozen embryo transfer at Hai Phong Maternity Hospital. Research methods: retrospective description. Results: The clinical pregnancy rate in the study was 72.4%. The mean serum progesterone (P4) levels prior to embryo transfer in the study group were 11.22 ± 3.98ng/mL. The ROC curve showed a significant predictive value of pre-embryonic serum P4 concentrations for clinical pregnancy rates, a high value area under the curve (AUC) of 0.6628. The optimal threshold value for predicting P-level clinical pregnancy is 9.2 ng/ml (sensitivity 77.53%, specificity 54.74%). The group of patients with Progesterone >9.2ng/ml was 2.62 times more likely to have a clinical pregnancy than the other group (95%CI = 1.17 – 5.86) statistically significant with p = 0.017.There was an inverse association between progesterone levels before 1-day embryo transfer and weight, with correlation coefficients p = 0.043 and r = - 0.1288. There were no significant differences in the concentration of age-related serum progesterone, uterine mucosa, BMI. Conclude: The clinical pregnancy rate in the sero-P4 group >9.2 ng/ml (76.4%) was statistically significant compared to the P4 group ≤ 9.2 ng/ml (55.3%) with p = 0.017. More research is needed to determine when to measure progesterone levels and find the right cut-off point for each assisted reproductive center. An individualized strategy for corpus luteal support in frozen embryo transfer and progesterone supplementation regimens should be introduced in cases with a low P4 equal to subcutaneous, intramuscular P4.