NHẬN XÉT GIÁ TRỊ MỘT SỐ YẾU TỐ TRONG TIÊN LƯỢNG SUY GAN CẤP Ở TRẺ EM

Abstract

Acute liver failure (ALF) is a rare syndrome characterized by rapid deterioration of normal liver function following an acute insult in a patient with no previously known underlying chronic liver disease. AHF in children is caused by many causes. Children with SGC need to be diagnosed the cause and prognosis in order to have the manage to minimize complications and death. Descriptive study was conducted on 94 AHF children. The average age of patients is 10 months (2 days- 14 years old). The highest age group was infants, accounting for 44.7% (n = 43), followed by children with 43.6% (n = 42). Older children (≥ 12 years) and infants had a low rate of 7.4% (n = 7) and 4.3% (n = 4). There is no gender difference in incidence. The most common causes of AHF are metabolic diseases (23.4%). In which, Wilson disease, urea cycle metabolic disorder, and citrin deficiency are the main diseases. The group of unknown etiology AHF is 47.9%. Jaundice, hepatic encephalopathy and hepatic atrophy are common symptoms in patients with a poor prognosis. INR>4.2 is the highest predictive test with with AUC = 0.74, sensitivity 72.1%, specificity 74.5%, positive predictive value 68, 9%, a negative predictive value of 75.5%. Bilirubin value ≥ 300µmol/l is a moderate prognostic value with AUC≥ 0.7.