NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ DI TRUYỀN CỦA NHỮNG BỆNH NHÂN VÔ SINH KHÔNG CÓ TINH TRÙNG KHÔNG DO TẮC

Abstract

We examined 501 patients with non-obstructive azoospermia to evaluate clinical, subclinical, and genetic characteristics. The results show that the average age of patients in the study was 29.8 ± 5.5 years. Primary infertility accounts for the majority, with a rate of 90.3%. There was 38.6% of patients had a history of mumps orchitis. The average level of FSH, LH, Testosterone were  31.6 ± 16.5mIU/ml, 15.5 ± 10mIU/ml, 12.8 ± 7.13 nmol/l, respectively. The prevalence of chromosomal abnormalities was 30.7%. Of these, the chromosomal quantity abnormalities with Karyotype 47, XXY (Klinefelter syndrome) accounted for 27.3%. The incidence of AZF microdeletion was 13.8%. Of these, AZFc deletion was the most common at the rate of 42.1, AZFa deletion, which accounted for 2.6%, were the least prevalent, and the frequency of AZFd deletion was 5.3%. However, there was no single AZFb deletion, which combined with other AZF deletions with 34,2%.Our research shows that mumps orchitis and chromosomal abnormalities are the leading causes of azoospermia. Screening for genetic abnormalities plays an important role in infertile patients with non-obstructive azoospermia.