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EVALUATION OF THE EFFICACY OF PROPHYLACTIC TREATMENT OF PRETERM BIRTH IN PREGNANT WOMEN WITH A SHORT CERVIX WITH VAGINAL PROGESTERONE
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Abstract
Objective: To evaluate the efficacy of prophylactic treatment of preterm birth in pregnant women with a short cervix with vaginal progesterone. Subjects and research methods: A non-controlled intervention study involved 65 pregnanciesat 19 - 23 weeks and 6 days gestation at the National Hospital Obstetrics and Gynecology are determined by vaginal ultrasound to have a length of the cervix ≤ 25mm and met the inclusive and exclusive criteria . Pregnant women received prophylactic treatment with 1 tablet vaginal Utrogestan in the evening continuously from enrollment to the end of the 36-week pregnancy. Research results: the rate of preterm birth <28 weeks accounted for 6.1%; less than 34 weeks 12.3%, less than 35 weeks 16.9% and under 37 weeks 33.8%. The number of pregnant women who did not give birth prematurely (≥37 weeks) was: 66.2%. Postpartum status: 12.3% of children die, 87.7% of children live healthy; 81.5% of children were ≥ 2,500 grams and 18.5% were <2,500 grams. Conclusion: Progesterone prophylaxis for pregnant women with a short cervix is effective in reducing the rate of preterm birth.
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Keywords
preterm birth, cervical length, Progesterone
References
2. Romero R. Vaginal progesterone to reduce the rate of preterm birth and neonatal morbidity: a solution at last. Women's health (London, England). 2011;7(5):501-4.
3. Romero R, Nicolaides KH, Conde-Agudelo A, O'Brien JM, Cetingoz E, Da Fonseca E, et al. Vaginal progesterone decreases preterm birth ≤ 34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study. Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2016;48(3):308-17.
4. Hassan SS, Romero R, Vidyadhari D, Fusey S, Baxter JK, Khandelwal M, et al. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2011;38(1):18-31.
5. Romero R, Conde-Agudelo A, El-Refaie W, Rode L, Brizot ML, Cetingoz E, et al. Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data. Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2017;49(3):303-14.
6. Norman JE, Marlow N, Messow C-M, Shennan A, Bennett PR, Thornton S, et al. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet (London, England). 2016;387(10033):2106-16.
7. Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH. Progesterone and the risk of preterm birth among women with a short cervix. The New England journal of medicine. 2007;357(5):462-9.
8. O'Brien JM, Adair CD, Lewis DF, Hall DR, Defranco EA, Fusey S, et al. Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double-blind, placebo-controlled trial. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2007;30(5):687-96.
9. Rode L, Klein K, Nicolaides KH, Krampl-Bettelheim E, Tabor A. Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo-controlled trial on the effect of vaginal micronized progesterone. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2011;38(3):272-80.