NGHIÊN CỨU TÁC DỤNG TRÊN TUẦN HOÀN, HÔ HẤP VÀ MỘT SỐ TÁC DỤNG KHÔNG MONG MUỐN KHÁC CỦA PHƯƠNG PHÁP AN THẦN BẰNG PROPOFOL DO BỆNH NHÂN TỰ ĐIỀU KHIỂN (PCS) ĐỂ CHỌC HÚT NOÃN THỤ TINH TRONG ỐNG NGHIỆM

Abstract

Objectives: Research the effects on circulation, respiration and side effects of patient-controlled sedation (PCS) with propofol for oocyte retrieval in in vitro fertilization. Methods: Prospective, randomized, comparative clinical trial, 60 patients with oocyte retrieval were randomly assigned to 2 groups. Group 1 (PCS group, n1 = 30) used patient-controlled sedation (Propfol 1%, 20mg each time the patient presses the machine, without setting the refractory period. n2 = 30) was the usual intravenous anesthetic group (Propofol 1% dose 2mg/kg intravenous intermittent controlled by the anesthesiologist).Patients in both groups received 0.05 mg 50 mcg fentanyl intravenous injection and paracervical anesthesia with 100mg lidocaine 1% bilaterally.We evaluated changes in circulation, changes in respiration and other undesirable effects such as decreased breathing, dizziness, nausea, and vomiting. vomiting, pain at injection site, hiccups. Results: Patient-controlled sedation with propofol is circulatory and respiratory stable and has fewer side effects than intermittent intravenous injection with propofol: Decreased breathing (6.7% vs. with 30%), dizziness (10% vs 50%), injection site pain (10% vs 27%), nausea (10% vs 16.7%). There were no cases of serious complications such as respiratory failure, hypotension, reflux. Conclusion: The method of patient-controlled sedation (PCS) with Propofol, combined with paracervical anesthesia with lidocaine in oocyte retrieval is stable in circulation, with few adverse effects.