INVESTIGATION ON MICROBIOLOGY AND ANTIBIOTIC RESISTANCE OF SOME COMMON BACTERIA IN PATIENTS WITH SEVERE DEEP NECK INFECTIONS AT CHO RAY HOSPITAL FROM 2019-2022
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Abstract
Background: Effective empiric antimicrobial treatment is important in deep neck infections, especially in severe cases. Objective: To investigate the microbiology and antibiotic resistance of common bacteria in severe deep neck infections to assist in the selection of initial antibiotic therapy. Methods: We did a retrospectively and prospectively descriptive study in cases of severe deep neck infections treated at Cho Ray Hospital from 12/2019 to 7/2022 with culture and sensitivity tests. Results: We recorded 99 cases of severe deep neck infections that fulfilled the sampling criteria. The median age was 57,3 ± 13,3 years. Microorganisms were successfully isolated in 67 cases (67.7%). Streptococcus sp was the most common bacteria (43.4%), followed by Klebsiella pneumoniae (19.2%), Staphylococcus aureus (6.1%), and Escherichia coli (3.0%). Streptococcus sp was highly resistant to clindamycin (60.0%), tetracycline (54.6%), and macrolides (40–55.0%). Klebsiella pneumoniae was 100% resistant to ampicillin. There was increased antibiotic resistance of microorganisms isolated to Cephalosporins. Vancomycin, linezolid, and carbapenems showed 100% sensitivity against all microorganisms isolated. Conclusion: Vancomycin, linezolid and carbapenems should be considered for initial antibiotic therapy of severe deep neck infections.
Article Details
Keywords
Deep neck infections, antibiotic resistance, complications
References
2. Umihanic S, Umihanic S, Ramic N, Kamenjakovic S, Tihic N, Mahmutovic E. Predictors of poor outcome of deep neck infections. Medeniyet Med J. 2018;33(1):28-32. doi:10.5222/mmj.2018.49140
3. James M. Christian, Charles B. Felts, Nicholas A. Beckmann, M. Boyd Gillespie. Deep Neck and Odontogenic Infections. In: Paul Flint, Bruce Haughey, Valerie Lund, et al, eds. Cummings Otolaryngology – Head and Neck Surgery. 7 ed. Elsevier Inc.; 2021:141-154:chap 9.
4. Trần Anh Bích, Trần Minh Trường. Nhiễm trùng cổ sâu trên bệnh nhân đái tháo đường: so sánh hình ảnh lâm sàng và kết quả điều trị với bệnh nhân không đái tháo đường từ 1/2005 đến 9/2006. Tạp chí Y học thành phố Hồ Chí Minh. 2006;11(1)
5. Võ Thanh Hà. Khảo sát vi trùng áp dụng trong điều trị nhiễm trùng cổ sâu tại bệnh viện Chợ Rẫy. Luận án chuyên khoa cấp II. Đại học Y Dược thành phố Hồ Chí Minh; 2016.
6. Mejzlik J, Celakovsky P, Tucek L, et al. Univariate and multivariate models for the prediction of life-threatening complications in 586 cases of deep neck space infections: retrospective multi-institutional study. J Laryngol Otol. Sep 2017;131(9):779-784. doi:10.1017/s0022215117001153
7. Huang TT, Tseng FY, Yeh TH, Hsu CJ, Chen YS. Factors affecting the bacteriology of deep neck infection: a retrospective study of 128 patients. Acta Otolaryngol. Apr 2006;126(4):396-401. doi:10.1080/00016480500395195
8. Trương Thiên Phú, Lê Hoài Cường, Nguyễn Tiến Thành, al e. Khuynh Hướng Đề Kháng Kháng Sinh Của Các Loại Vi Khuẩn Thường Gặp Tại Bệnh Viện Chợ Rẫy Năm 2019. Hội Nghị Khoa Học Thường Niên Bệnh Viện Chợ Rẫy. 2020;