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Date Published: 24/03/2023
Abstract Views: 158
Views PDF: 110
DOI: https://doi.org/10.51298/vmj.v524i1B.4802
Issue
Vol. 524 No. 1B (2023)
Section
Các bài báo
How to Cite
Nguyễn, T. H. ., Đỗ , K. B. ., Trần , T. N. L. ., Nguyễn, T. S. ., Phạm , T. H. T., & Nguyễn, O. O. . (2023). EVALUATION OF THE RELATIONSHIP BETWEEN LEPTIN LEVELS AND SOME CARDIAC MORPHOLOGICAL AND FUNCTIONAL INDICATORS IN TYPE 2 DIABETES PATIENTS WITH OVERWEIGHT OR OBESITY. Vietnam Medical Journal, 524(1B). https://doi.org/10.51298/vmj.v524i1B.4802

EVALUATION OF THE RELATIONSHIP BETWEEN LEPTIN LEVELS AND SOME CARDIAC MORPHOLOGICAL AND FUNCTIONAL INDICATORS IN TYPE 2 DIABETES PATIENTS WITH OVERWEIGHT OR OBESITY

Thu Hiền Nguyễn1,, Kim Bảng Đỗ 2, Thị Ngọc Lan Trần 2, Tiến Sơn Nguyễn3, Thị Hồng Thi Phạm 2, Oanh Oanh Nguyễn3
1 Thai Nguyen Central hospital
2 Bach Mai hospital
3 103 Military Hospital Vietnam Military Medical Academy

Main Article Content

Abstract

Objectives: To assess the relationship between leptin concentrations and some cardiac morphological and functional indicators in type 2 diabetes patients with overweight or obesity. Subjects and methods: A descriptive, cross-sectional study and comparison among three groups: group of type 2 diabetes patients with overweight or obesity (study group); group of type 2 diabetes patients without overweight or obesity (disease-control), and control group. Results: 266 participants were divided into three groups. Serum leptin levels in the study group was 0.43 (0.35 - 0.53) (ng/mL), in the disease-control: 0.42 (0.34 - 0.52) (ng/mL) and in the control group: 0.46 (0.36 - 0.60) (ng/mL) (p > 0.05). In the study group, patients with increased leptin level had higher left ventricular mass index compared to those with decreased leptin level (p < 0.05). Leptin concentration had negative correlation with interventricular septum e’-wave, lateral wall e’-wave; positive correlation with E/e’ratio (interventricular septum, lateral wall, mean), left ventricular posterior wall thickness in diastole, left ventricular muscle mass, left ventricular mass index (p < 0.05). Conclusion: In type 2 diabetes patients with overweight or obesity, leptin levels have an effect on left ventricular posterior wall thickness in diastole, left ventricular muscle mass, left ventricular muscle mass index and some cardiac functional indices (e'-wave and E/e').

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References

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