EFFICACY OF 3% HYPERTONIC SALINE NEBULIZER IN ACUTE BRONCHIOLITIS IN CHILDREN UNDER 2 YEARS OLD AT BACH MAI HOSPITAL

Thúy Giang Nguyễn1,, Tiến Dũng Nguyễn2, Hữu Hiếu Nguyễn2, Văn Bàn Trần 3
1 Hong Ngọc hospital
2 Bach Mai hospital
3 Hong Ngoc hospital

Main Article Content

Abstract

Objective: To evaluate the effectiveness of 3% sodium chloride aerosol method in the treatment of acute bronchiolitis in children under 2 years old at Bach Mai hospital. Subjects and methods: Prospective descriptive study, 441 patients under 2 years old, diagnosed with acute bronchiolitis, both groups were nebulized 3 times/day, 4ml each time. The NC group nebulized 3% sodium chloride, the control group nebulized 0.9% sodium chloride. The children were treated for other symptoms according to their clinical condition. Results: The number of children under 12 months in both groups accounted for 80%. The respiratory rate, heart rate and SpO2 after aerosolization of both groups decreased compared to the time of entry (p<0.05). The mean MCBS scores of the two groups were low with the mean score of the NC group of 1.45 ± 0.69 lower than that of the control group of 1.52 ± 0.67 (p<0.05). The symptoms of wheezing on day 3 and day 5, at the NC group was 64.49% and 19.2%, at the control group was 72.7% and 24.5%, respectively (p>0.05). The symptoms chest retraction on day 5, at the NC group was 2.89% and the control group was 3.6% with p<0.05. Conclusion: The 3% sodium chloride aerosol group had a greater improvement in MCBS score than the 0.9% sodium chloride aerosol group. The symptoms of wheezing, chest indrawing, crackles were reduced more in the group of 3% sodium chloride aerosol.

Article Details

References

1. Nguyễn Ngọc Phúc (2019), "Đặc điểm viêm tiểu phế quản trung bình ở trẻ em điều trị với khí dung nước muối ưu trương natri clorua 3% và salbutamol tại bệnh viện Nhi Đồng 1", Nghiên cứu Y học - Y Học TP. Hồ Chí Minh. 23, tr. 116 - 121.
2. Chen, Yen-Ju (2014), "Nebulized Hypertonic Saline Treatment Reduces both Rate and Duration of Hospitalization for Acute Bronchiolitis in Infants: An Updated Meta-Analysis", Pediatrics and Neonatology. 55(6), tr. 431-8.
3. Hsieh, Chia-Wen (2020), "Exploring the efficacy of using hypertonic saline for nebulizing treatment in children with bronchiolitis: a meta-analysis of randomized controlled trials", BMC Pediatrics. 20, tr. 434.
4. Maguire, Chin (2015), "Hypertonic saline (HS) for acute bronchiolitis: Systematic review and meta-analysis", BMC Pulmonary Medicine. 15, tr. 1-17.
5. Meissner, H. Cody (2016), "Viral Bronchiolitis in Children", The New England Journal of Medicine. 374, tr. 62-72.
6. Nguyen Ngoc Sang at al (2021), "Clinical Epidemiological Characteristics and Risk Factors for Severe Bronchiolitis Caused by Respiratory Syncytial Virus in Vietnamese Children", International Journal of Pediatrics. 2021.
7. Sharma, Bhagwan S (2013), "Hypertonic (3%) Saline Vs 0.9% Saline Nebulization for Acute Viral Bronchiolitis: A Randomized Controlled Trial", Indian Pediatr. 50(8), tr. 743-7.
8. Zhang, Linjie (2008), "Nebulized hypertonic saline solution for acute bronchiolitis in infants", Cochrane Database of Systematic Reviews(4).
9. Zhang, Linjie (2017), "Nebulised hypertonic saline solution for acute bronchiolitis in infants (Review)", Cochrane Database of Systematic Reviews(12), tr. 1-90.