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Date Published: 30/03/2023
Abstract Views: 348
Views PDF: 316
DOI: https://doi.org/10.51298/vmj.v524i2.4852
Issue
Vol. 524 No. 2 (2023)
Section
Các bài báo
How to Cite
Nguyễn, T. T. ., Võ , T. M. C. ., Nguyễn, A. T. ., Nguyễn, Đăng T., & Ngô, K. Đức . (2023). IN VITRO ANTIOXIDANT ACTIVITIES OF LEAF EXTRACT OF MELASTOMA CANDIDUM D. DON USING DPPH AND ABTS METHODS. Vietnam Medical Journal, 524(2). https://doi.org/10.51298/vmj.v524i2.4852

IN VITRO ANTIOXIDANT ACTIVITIES OF LEAF EXTRACT OF MELASTOMA CANDIDUM D. DON USING DPPH AND ABTS METHODS

Thanh Tuyền Nguyễn1,, Thị Minh Châu Võ 1, Anh Tuấn Nguyễn1, Đăng Tiến Nguyễn1, Kiến Đức Ngô1
1 University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

Oxidative stress is the process of generating free radicals including reactive oxygen and nitrogen species (ROS and RNS), which are linked to the development of diseases, including cancer, cardiovascular, and neurological diseases. The present study aims to determine the in vitro antioxidant activities of ethanolic crude extract and the fractions of Melastoma candidum D. Don leaf extract using DPPH and ABTS methods. The results showed that ethyl acetate fraction possessed the highest total phenolic content and total flavonoid content. Ethanolic crude extract and all of the fractions of chloroform, ethyl acetate, n-butanol, aqueous had in vitro antioxidant activities. In which, ethyl acetate fraction had the highest effect with IC50 of 15,34 ± 0,80 μg/mL using DPPH method (higher than that of acid ascorbic 4,38 ± 0,36 µg/ml) and IC50 of 4,49 ± 0,12 μg/mL using ABTS method (higher than that of acid ascorbic 2,39 ± 0,33 μg/mL). The M. candidum leaves possessed potential antioxidant activities that could be a promising source of natural antioxidant.

Article Details

Keywords

Melastoma candidum D., antioxidant, DPPH, ABTS.

References

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