ĐÁNH GIÁ TÌNH TRẠNG DI CĂN HẠCH CỔ VÀ MỐI LIÊN QUAN TỚI ĐẶC ĐIỂM BỆNH HỌC UNG THƯ SÀN MIỆNG

Abstract

Objectives: To evaluate cervical lymph node metastasis and its relationship with clinicopathological characteristics in patients with floor-of-mouth carcinoma. Patients and methods: A cross-sectional descriptive study on 48 patients with floor-of-mouth carcinoma without clinical lymph node metastasis who underwent extensive resection with selective cervical lymphadenectomy at National Cancer Hospital from 01/2015 to 01/2020. Results: In 48 patients studied, the mean age was 56.8 (41 - 75); male/female ratio = 7; most patients have a history of smoking and drinking alcohol; 29.2% of patients had midline-involved tumors; The most common tumor types are exophytic and ulcerative combined (45.8%); mean tumor size 2.13 ± 0.79cm. Most DOI >5mm; postoperative stage pT1,2 accounted for mainly (79.2%); the mean number of removed lymph nodes was 14.0 ± 7.1; The lymph node metastasis rate was 22.9%. Lymph node metastasis rate was higher in tumors >2cm compared with ≤2cm (36% vs 8.7%; OR = 2,593, p=0.025), DOI >5mm vs ≤5mm (42.1% vs. 8.3%; OR = 8, p = 0.044). The lymph node metastasis rate increased gradually by stage pT1, pT2, and pT3 (6.7%, 21.7%, and 50% respectively) with p=0.041. Age, gender, morphology, and tumor location are not associated with lymph node metastasis rate. Conclusions: Floor of mouth cancer often metastasizes to lymph nodes early. Cervical lymph node metastasis was associated with tumor size, depth of invasion, and postoperative stage.