NGHIÊN CỨU TỶ LỆ KLEBSIELLA PNEUMONIAE SINH AMPC BETA-LACTAMASE VÀ GEN MÃ HÓA ENZYME AMPC BETA-LACTAMASE

Abstract

The study was carried out at Can Tho City General Hospital and samples were tested at MEDLATEC Can Tho from January 2022 to Decenber 2022. Study design: Cross-sectional description, convenient sampling, the number of strains collected was 262 samples. Results: Klebsiella pneumoniae strains with AmpC (+)/ESBL (-) had the highest resistance rates on beta-lactam groups and also on combination antibiotics with beta-lactam inhibitors, the highest resistance was Ampicillin and Amox- Clavulanate had a resistance rate of 93.75%. Next was the second generation and third generation Cephalosporin antibiotics (Cefuroxime, Ceftazidime, Cefotaxime, Ceftriaxone) with resistance rates from 68.75% to 81.25%. The rate of resistance to the 4th generation Cephalosporin antibiotic group (Cefepime) was also resistant to 62.5%. Carbapenem group is also resistant to 50% of Imipenem and Meropenem; and 56.3% - higher for two antibiotics of the same group, Doripenem, Ertapenem. The rate of resistance to quinolones, which were also resistant to high levels of Levofloxacin, was 50% and ciprofloxacin 56.3%. The lowest resistance rate was Amikacin 37.5%. Conclusion: Klebsiella pneumoniae was resistant to most currently used antibiotics with a high rate, with both the latest generation antibiotics such as 4th generation cephalosporins and carbapenem and quinlon antibiotics with rates above 50%.