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Date Published: 12/04/2023
Abstract Views: 362
Views PDF: 154
DOI: https://doi.org/10.51298/vmj.v525i1A.4910
Issue
Vol. 525 No. 1A (2023)
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How to Cite
Đỗ , H. N., Nguyễn, T. Q. ., & Nguyễn, T. T. . (2023). TREATMENT RESULTS OF R-GEMOX REGIMEN IN RELAPSED/REFRACTORY B CELL LYMPHOMA WITHOUT HIGH-DOSE CHEMOTHERAPY INDICATIONS AT THE K HOSPITAL 2019-2022. Vietnam Medical Journal, 525(1A). https://doi.org/10.51298/vmj.v525i1A.4910

TREATMENT RESULTS OF R-GEMOX REGIMEN IN RELAPSED/REFRACTORY B CELL LYMPHOMA WITHOUT HIGH-DOSE CHEMOTHERAPY INDICATIONS AT THE K HOSPITAL 2019-2022

Huyền Nga Đỗ 1,, Tiến Quang Nguyễn1, Thanh Tùng Nguyễn1
1 k hospital

Main Article Content

Abstract

Objectives: To evaluate the treatment results and some side effects of R-GEMOX regimen in relapsed/refractory B-cell non-Hodgkin's lymphoma without high-dose chemotherapy indications at the K hospital from 2019 to 2022; Subjects and methods: A prospective, cross-sectional study performed on 40 patients with relapsed/refractory B cell non-Hodgkin lymphoma treated at the Hematologic Oncology Department, K Hospital from 05/2019-11/2022. Results: Mean age was 61.7; male/female ratio=1; 90% of the patients received 1 prior chemotherapy regimen. The median time from last regimen to R-GEMOX was 10 months. Patients with stage 4 when relapsed/refractory accounted for 35%. Most of the patients with histopathology could be DLBCL, accounting for 87.5%. Overall response rate was 60%, of which the rate of complete response was 17.5%; partial response was 42.5%; Stable disease rate was 2.5%; disease progression rate was 37.5%; Toxicity grade 3 or higher accounted for 17.5%. The median progression free survival was 15 months. The median overall survival was 20 months. Conclusion: R-GEMOX regimen prolongs progression-free survival as well as overall survival and is safe for patients with relapsed/refractory B-cell non-Hodgkin lymphoma without high-dose chemotherapy indications.

Article Details

Keywords

R/R NHL (Relapsed/Refractory B-cell non-Hodgkin lymphoma)

References

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