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Date Published: 12/04/2023
Abstract Views: 356
Views PDF: 163
DOI: https://doi.org/10.51298/vmj.v525i1A.4942
Issue
Vol. 525 No. 1A (2023)
Section
Các bài báo
How to Cite
Nguyễn, T. Q. N. ., Lê, Đặng T. N. ., Nhan , T. P., Trần , T. N. V. ., Nguyễn, T. T. ., Trần , T. H. N. ., Nguyễn, D. D. K. ., Nguyễn, T. H. Y. ., & Phạm , Đình L. . (2023). COST-EFFECTIVENESS ANALYSIS OF ROFLUMILAST AS AN ADD-ON TO TRIPLE INHALED THERAPY LABA/LAMA/ICS VS LABA/LAMA/ICS IN PATIENTS WITH SEVERE AND VERY SEVERE COPD IN VIETNAM. Vietnam Medical Journal, 525(1A). https://doi.org/10.51298/vmj.v525i1A.4942

COST-EFFECTIVENESS ANALYSIS OF ROFLUMILAST AS AN ADD-ON TO TRIPLE INHALED THERAPY LABA/LAMA/ICS VS LABA/LAMA/ICS IN PATIENTS WITH SEVERE AND VERY SEVERE COPD IN VIETNAM

Thị Quỳnh Nga Nguyễn1,, Đặng Tú Nguyên Lê1, Trí Phát Nhan 2, Thị Ngọc Vân Trần 3, Thu Thảo Nguyễn4, Thị Hồng Nguyên Trần 1, Dương Duy Khoa Nguyễn1, Thị Hải Yến Nguyễn1, Đình Luyến Phạm 1
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 AstraZeneca Việt Nam company
3 AstraZeneca Viet Nam company
4 Nguyen Tri Phuong hospital

Main Article Content

Abstract

Objectives: Cost-effectiveness analysis of Roflumilast as an add-on to triple inhaled therapy LABA/LAMA/ICS vs triple inhaled therapy in patients with severe and very severe COPD in Vietnam. Research methods: A probabilistic Markov cohort model was developed, including three main states: severe COPD, very severe COPD, and death. This study was carried out from the Social Health Insurance perspective, with the base case time horizon being 30 years and a one-month cycle. Results: The incremental cost-effectiveness ratio (ICER) for LABA/ LAMA/ICS/Roflumilast was 168,577,946 VND/QALY compared with triple inhaled therapy. Input parameters including the cohort’s starting age, the monthly transition probability from severe to very severe COPD in patients receiving LABA/LAMA/ICS/ Roflumilast, discount rate for effectiveness and cost, and standardized mortality rate in patients with severe COPD influenced the overall cost-effectiveness the most. LABA/LAMA/ICS/Roflumilast had a 100% probability of being cost-effective at the threshold of 3 times GDP per capita as recommended by WHO. Conclusion: From the payer perspective, Roflumilast as an add-on to triple inhaled therapy LABA/LAMA/ICS was a cost-effective treatment option compared with triple therapy LABA/LAMA/ICS for patients with severe or very severe COPD in Vietnam.

Article Details

Keywords

Roflumilast, severe and very severe COPD, Cost-effectiveness analysis, Vietnam.

References

1. GOLD Committee. Global Strategy For The Diagnosis, Management, And Prevention Of Chronic Obstructive Pulmonary Disease. 2021.
2. Martinez FJ, Calverley PMA, Goehring U, Brose M, Fabbri LM, Rabe KF. Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial. Lancet. 2015;6736(14):1–10.
3. Pham KHT, Vũ VG, Nguyễn HTT. Chi phí y tế trực tiếp trong điều trị bệnh phổi tắc nghẽn mạn tính theo phân loại gold dựa trên phân tích dữ liệu lớn từ bảo hiểm y tế Việt Nam năm 2020. Tạp chí Y học Việt Nam. 2022;
4. Tổng điểu tra Dinh dưỡng. Báo cáo của Tổng điểu tra Dinh dưỡng Việt nam năm 2019-2020. 2021.
5. Kiff C, Ruiz S, Varol N, Gibson D, Davies A, Purkayastha D. Cost-effectiveness of roflumilast as an add-on to triple inhaled therapy vs triple inhaled therapy in patients with severe and very severe COPD associated with chronic bronchitis in the UK. Int J COPD. 2018;13:2707–20.
6. Samyshkin Y, Schlunegger M, Haefliger S, Ledderhose S, Radford M. Cost-effectiveness of roflumilast in combination with bronchodilator therapies in patients with severe and very severe COPD in Switzerland. Int J Chron Obstruct Pulmon Dis. 2013;8:79.
7. Hertel N, Kotchie RW, Samyshkin Y, Radford M, Humphreys S, Jameson K. Cost-effectiveness of available treatment options for patients suffering from severe COPD in the UK: A fully incremental analysis. Int J COPD. 2012;7:183–99.