Article Sidebar

PDF
Date Published: 20/04/2023
Abstract Views: 470
Views PDF: 158
DOI: https://doi.org/10.51298/vmj.v525i1B.5025
Issue
Vol. 525 No. 1B (2023)
Section
Các bài báo
How to Cite
Nghiêm , P. T. ., Lưu, N. B. T. ., Võ , T. M. ., & Võ , T. M. . (2023). ROLE OF ULTRASOUND IN DIAGNOSIS OF ENDOMETRIAL CANCER. Vietnam Medical Journal, 525(1B). https://doi.org/10.51298/vmj.v525i1B.5025

ROLE OF ULTRASOUND IN DIAGNOSIS OF ENDOMETRIAL CANCER

Phương Thảo Nghiêm 1,, Ngọc Bảo Trân Lưu1, Thanh Mai Võ 2, Thanh Mai Võ 2
1 Pham Ngoc Thach University of Medicine
2 Tu Du hospital

Main Article Content

Abstract

Objective: To describe the sonographic features and to define role of ultrasound in diagnostic of endometrial cancer (EC) using the International Endometrial Tumor Analysis (IETA) terminology. Methods: A cross-sectional retrospective study of 343 women with biopsy endometrial undergoing standardized transvaginal grayscale and Doppler ultrasound (US) examination according to the IETA study protocol. Results: Median age was 44,50± 8,14, patients with BMI ≥ 25 accounted for 46.4%. There were 9 cases (2,6%) of endometrial cancer. The mean endometrial thickness (ET) of endometrial cancer group was 22,82±18,52mm, higher than benign group (11,72±6,67mm), p=0,001. The majority of EC had non-uniform echogenicity (77,8%), not-defined endometrial midline (66,7%), not-defined endometrial-myometrial junction (66,7%), no fluid in the endometrial cavity (77,8%). When there is no sign ‘’not defined endometrial-myometrial junction ‘’, the risk of EC is decreased by 96% (p<0,001).  On Doppler ultrasound, multiple dominant vessels and Doppler score > 2 increased the risk of endometrial cancer with an OR of 90.9 and 66.7 times, respectively (p<0.001). The value of US according to IETA in diagnosing EC is as follow: ET≥ 15,8mm, not-defined endometrial midline, not-defined endometrial-myometrial junction have sensitivity of 66.67%, specificity was 73.95%, 82.63% and 92.11%, respectively. Conclusion: a detailed and thorough endometrial assessment according to the IETA terminology will be necessary in early diagnosis of EC. 

Article Details

Keywords

ultrasound, endometrial cancer, International Endometrial Tumor Analysis (IETA).

References

1. Didkowska J, Wojciechowska U, Michalek IM, Caetano Dos Santos FL. Cancer incidence and mortality in Poland in 2019. Sci Rep. 2022;12(1):10875. Published 2022 Jun 27. doi:10.1038/s41598-022-14779-6.
2. Trần Văn Thuấn, Lê Văn Quảng. Ung thư nội mạc tử cung. Hướng dẫn và chẩn đoán một số bệnh ung thư thường gặp. Nhà xuất bản Y học, Hà Nội; 2019:327-336.
3. Carey MS, Gawlik C, Fung-Kee-Fung M, Chambers A, Oliver T; Cancer Care Ontario Practice Guidelines Initiative Gynecology Cancer Disease Site Group. Systematic review of systemic therapy for advanced or recurrent endometrial cancer. Gynecol Oncol. 2006;101(1):158-167. doi:10.1016/j.ygyno.2005.11.019.
4. Tejerizo-García A, Jiménez-López JS, Muñoz-González JL, et al. Overall survival and disease-free survival in endometrial cancer: prognostic factors in 276 patients. Onco Targets Ther. 2013;9:1305-1313. Published 2013 Sep 16. doi:10.2147/OTT.S51532.
5. Ferrazzi E, Torri V, Trio D, Zannoni E, Filiberto S, Dordoni D. Sonographic endometrial thickness: a useful test to predict atrophy in patients with postmenopausal bleeding. An Italian multicenter study. Ultrasound Obstet Gynecol. 1996;7(5):315-321. doi:10.1046/j.1469-0705.1996.07050315.x.
6. Leone FP, Timmerman D, Bourne T, et al. Terms, definitions and measurements to describe the sonographic features of the endometrium and intrauterine lesions: a consensus opinion from the International Endometrial Tumor Analysis (IETA) group. Ultrasound Obstet Gynecol. Jan 2010;35(1):103-12. doi:10.1002/uog.7487.
7. Timmerman D, Valentin L, Bourne TH, Collins WP, Verrelst H, Vergote I. International Ovarian Tumor Analysis (IOTA) Group. Terms, definitions and measurements to describe the sonographic features of adnexal tumors: a consensus opinion from the International Ovarian Tumor Analysis (IOTA) Group. Ultrasound Obstet Gynecol. 2000; 16: 500–505.
8. Trương Thị Mỹ Linh. Tỷ lệ tăng sinh nội mạc tử cung ở phụ nữ xuất huyết tử cung bất thường và các yếu tố liên quan. Trường Đại học Y khoa Phạm Ngọc Thạch; 2020.
9. Giannella L, Mfuta K, Setti T, Cerami LB, Bergamini E, Boselli F. A risk-scoring model for the prediction of endometrial cancer among symptomatic postmenopausal women with endometrial thickness > 4 mm. Biomed Res Int. 2014;2014:130569. doi:10.1155/2014/130569
10. Madkour NM. An ultrasound risk-scoring model for prediction of endometrial cancer in post-menopausal women (using IETA terminology). Middle East Fertility Society Journal. 2017. doi: 10.1016/j.mefs.2017.01.009.