ROLE OF ULTRASOUND IN DIAGNOSIS OF ENDOMETRIAL CANCER

Phương Thảo Nghiêm 1,, Ngọc Bảo Trân Lưu1, Thanh Mai Võ 2, Thanh Mai Võ 2
1 Pham Ngoc Thach University of Medicine
2 Tu Du hospital

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Abstract

Objective: To describe the sonographic features and to define role of ultrasound in diagnostic of endometrial cancer (EC) using the International Endometrial Tumor Analysis (IETA) terminology. Methods: A cross-sectional retrospective study of 343 women with biopsy endometrial undergoing standardized transvaginal grayscale and Doppler ultrasound (US) examination according to the IETA study protocol. Results: Median age was 44,50± 8,14, patients with BMI ≥ 25 accounted for 46.4%. There were 9 cases (2,6%) of endometrial cancer. The mean endometrial thickness (ET) of endometrial cancer group was 22,82±18,52mm, higher than benign group (11,72±6,67mm), p=0,001. The majority of EC had non-uniform echogenicity (77,8%), not-defined endometrial midline (66,7%), not-defined endometrial-myometrial junction (66,7%), no fluid in the endometrial cavity (77,8%). When there is no sign ‘’not defined endometrial-myometrial junction ‘’, the risk of EC is decreased by 96% (p<0,001).  On Doppler ultrasound, multiple dominant vessels and Doppler score > 2 increased the risk of endometrial cancer with an OR of 90.9 and 66.7 times, respectively (p<0.001). The value of US according to IETA in diagnosing EC is as follow: ET≥ 15,8mm, not-defined endometrial midline, not-defined endometrial-myometrial junction have sensitivity of 66.67%, specificity was 73.95%, 82.63% and 92.11%, respectively. Conclusion: a detailed and thorough endometrial assessment according to the IETA terminology will be necessary in early diagnosis of EC. 

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References

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