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Date Published: 20/04/2023
Abstract Views: 143
Views PDF: 116
DOI: https://doi.org/10.51298/vmj.v525i1B.5071
Issue
Vol. 525 No. 1B (2023)
Section
Các bài báo
How to Cite
Nguyễn, T. M. H. ., Nguyễn, M. T. ., Trương , Đinh K. D. ., Hoàng, A. V. ., Bùi , Q. V. ., & Lâm , T. M. . (2023). THE RELATIONSHIP BETWEEN THE POLYMORPHISM AT rs9298814 OF IFNA17 GENE WITH THE DEVELOPMENT AND SEVERITY OF CHRONIC IMMUNE THROMBOCYTOPENIA. Vietnam Medical Journal, 525(1B). https://doi.org/10.51298/vmj.v525i1B.5071

THE RELATIONSHIP BETWEEN THE POLYMORPHISM AT rs9298814 OF IFNA17 GENE WITH THE DEVELOPMENT AND SEVERITY OF CHRONIC IMMUNE THROMBOCYTOPENIA

Thị Mộng Hồng Nguyễn1,, Minh Tuấn Nguyễn2, Đinh Kiều Diễm Trương 1, Anh Vũ Hoàng2, Quang Vinh Bùi 1, Thị Mỹ Lâm 1
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 THE CHILDREN’S HOSPITAL 1

Main Article Content

Abstract

Objectives: (1) To identify genetic variants of IFNA rs9298814 in immune thrombocytopenia (ITP) (2) To investigate the association between IFNA17 rs9298814 gene polymorphism with the severity and chronic ITP in children at Children’s Hospital 1. Research methodology: Descriptive study combined with rescuing for clinical data, genotyping for IFNA17 rs9298814 by Sanger sequencing method. Subjects: 30 healthy control and 205 patients with ITP in Department of Dengue Hemorrhagic Fever and Hematology – Children’s Hospital 1 from 01/2019 to 01/2020. Results and conclusion: For the SNP of IFNA17 rs9298814, the frequencies of the homozygous wild type (TT), the heterozygous (TG) and the homozygous mutant (GG) genotypes were 70,0%, 20,0%, and 10,0% in healthy and 31,7%, 49,3%, and 19,0% in ITP patient. The ratio of allele T/G in healthy and ITP are 48/12 and 231/179, p<0,05. In 205 cases, the chronic ITP is 23,4% (48 cases) and non-chronic ITP is 76,6% (157 cases). There is significant differences between cITP and non-cITP in the frequencies of genotypes (TT,TG and GG), with p<0,05; 15,9%, 60,5% and 23,6% for non-cITP; 83,3%, 12,5% and 4,2% for cITP, respectively. The number of platelet after 3 weeks in cITP patients for genotype (TT và TG+GG) are 18,4± 6,9/uL and 21,5 ±8,4/uL in that order. There was a negative correlation between SNP of IFNA17 T184G and chronic ITP.

Article Details

Keywords

immune thrombocytopenia; rs9298814, IFNA17 SNP

References

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