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Date Published: 21/07/2021
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DOI: https://doi.org/10.51298/vmj.v501i2.508
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Vol. 501 No. 2 (2021)
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Các bài báo
How to Cite
Trường Khanh, V. ., Quý Linh, N. ., Hải Linh, V. ., Trần Tiến, Đào ., Vân Khánh, T. ., Vân Khánh, T. ., & Huy Thịnh, T. . (2021). IDENTIFICATION OF CDH1 MUTATION IN DIFFUSE GASTRIC CANCER PATIENTS. Vietnam Medical Journal, 501(2). https://doi.org/10.51298/vmj.v501i2.508

IDENTIFICATION OF CDH1 MUTATION IN DIFFUSE GASTRIC CANCER PATIENTS

Vũ Trường Khanh, Nguyễn Quý Linh, Vũ Hải Linh, Đào Trần Tiến, Trần Vân Khánh, Trần Vân Khánh, Trần Huy Thịnh

Main Article Content

Abstract

Gastric cancer is one of five most common types of cancer worldwide. According to the Lauren classification, diffuse gastric cancer is one of three types of gastric cancer. It is characterized by poor differentiation with highly invasive and metastatic probability. The CDH1 gene encodes for the E-cadherin protein and plays an important role in cell-cell adhesion and maintenance of epithelial integrity. Because of these important functions, a CDH1 gene mutation increases the  risk  of  gastric  cancer.  CDH1 gene  mutations  have  been  shown  to  be one  of  two  molecular  mechanisms  responsible  for  diffuse  gastric  cancer. We performed genetic sequencing CDH1 gene of 30 patients that was diagnosis as diffuse gastric cancer. The results show that 15/30 patients had a mutation of CDH1 gene. Among of these, mutation in intron 1 c48+6 C > T is the most popular (33.3%), next is mutation in operator c1-285 C > A and in exon 8 c.1248 delT (20%).

Article Details

Keywords

Diffuse gastric cancer, mutation, CDH1

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