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Date Published: 21/07/2021
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DOI: https://doi.org/10.51298/vmj.v501i2.508
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Vol. 501 No. 2 (2021)
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Các bài báo
How to Cite
Trường Khanh, V. ., Quý Linh, N. ., Hải Linh, V. ., Trần Tiến, Đào ., Vân Khánh, T. ., Vân Khánh, T. ., & Huy Thịnh, T. . (2021). IDENTIFICATION OF CDH1 MUTATION IN DIFFUSE GASTRIC CANCER PATIENTS. Vietnam Medical Journal, 501(2). https://doi.org/10.51298/vmj.v501i2.508

IDENTIFICATION OF CDH1 MUTATION IN DIFFUSE GASTRIC CANCER PATIENTS

Vũ Trường Khanh, Nguyễn Quý Linh, Vũ Hải Linh, Đào Trần Tiến, Trần Vân Khánh, Trần Vân Khánh, Trần Huy Thịnh

Main Article Content

Abstract

Gastric cancer is one of five most common types of cancer worldwide. According to the Lauren classification, diffuse gastric cancer is one of three types of gastric cancer. It is characterized by poor differentiation with highly invasive and metastatic probability. The CDH1 gene encodes for the E-cadherin protein and plays an important role in cell-cell adhesion and maintenance of epithelial integrity. Because of these important functions, a CDH1 gene mutation increases the  risk  of  gastric  cancer.  CDH1 gene  mutations  have  been  shown  to  be one  of  two  molecular  mechanisms  responsible  for  diffuse  gastric  cancer. We performed genetic sequencing CDH1 gene of 30 patients that was diagnosis as diffuse gastric cancer. The results show that 15/30 patients had a mutation of CDH1 gene. Among of these, mutation in intron 1 c48+6 C > T is the most popular (33.3%), next is mutation in operator c1-285 C > A and in exon 8 c.1248 delT (20%).

Article Details

Keywords

Diffuse gastric cancer, mutation, CDH1

References

1. Siegel R.L., Miller K.D., và Jemal A. (2020). Cancer statistics, 2020. CA Cancer J Clin, 70(1), 7–30.
2. Rahman R., Asombang A.W., và Ibdah J.A. (2014). Characteristics of gastric cancer in Asia. World J Gastroenterol, 20(16), 4483–4490.
3. Ansari S., Gantuya B., Tuan V.P. và cộng sự. (2018). Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity. Int J Mol Sci, 19(8).
4. Hansford S., Kaurah P., Li-Chang H. và cộng sự. (2015). Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond. JAMA Oncol, 1(1), 23–32.
5. El-Husny A., Raiol-Moraes M., Amador M. và cộng sự. (2016). CDH1 mutations in gastric cancer patients from northern Brazil identified by Next- Generation Sequencing (NGS). Genet Mol Biol, 39(2), 189–198.
6. Choi J.-H., Kim Y.-B., Ahn J.M. và cộng sự. (2018). Identification of genomic aberrations associated with lymph node metastasis in diffuse-type gastric cancer. Exp Mol Med, 50(4), 1–11.
7. Camargo M.C., Goto Y., Zabaleta J. và cộng sự. (2012). Sex hormones, hormonal interventions, and gastric cancer risk: a meta-analysis. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol, 21(1), 20–38.
8. Oliveira C., Sousa S., Pinheiro H. và cộng sự. (2009). Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology, 136(7), 2137–2148.
9. Chen Q.-H., Deng W., Li X.-W. và cộng sự. (2013). Novel CDH1 germline mutations identified in Chinese gastric cancer patients. World J Gastroenterol WJG, 19(6), 909–916.