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INVESTIGATING THE CHARACTERISTICS OF SEVERAL PARAMETERS LIKE PERIPHERAL BLOOD CELLS, COAGULATION TESTS AND INFLAMMATORY MARKERS IN COVID-19 PATIENTS AT CAN THO CENTRAL GENERAL HOSPITAL
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Abstract
Background: Being infected with SARS-CoV-2 stimulates the immune responses, alternates the quantity and morphology of blood cells or even disorders in coagulation tests and inflammatory markers. Nevertheless, the functions of these parameters in classifying COVID-19 degrees of illness have been vague. Therefore, this study is operated to initially evaluate the classific capability of the abovementioned parameters in COVID-19 patients at hospital admission. Objective: To define the characteristics of several parameters like peripheral blood cells, coagulation tests and inflammatory markers in COVID-19 patients at admission to the hospital. Material and method: retrospective study was achieved on 269 COVID-19 patients over 18 years old, who were positive with SARS-CoV-2 virus confirmed by RT-PCR assay. This study was classified into 3 categories (according to the criteria published by the Ministry of Health): moderate, severe, and critical measure at Can Tho Central General Hospital from January 2021 to March 2022. Results: The average age of the study participants is 62,7 years old. Among common comorbidities, 61,7% are hypertension (n=139), followed by 42% diabetes (n=113); 20,4% chronic kidney diseases (n=55); 19,7% cardiovascular diseases (n=53). The statistical variation (p<0,05) is represented in parameters such as WBC, neutrophile (x109/L), neutrophile (%), lymphocyte (x109/L), lymphocyte (%), monocyte (x109/L), monocyte (%), eosinophile (x109/L), eosinophile (%), basophile (%), NLR, PT, INR, fibrinogen, D-Dimer, CRP, LDH, ferritin at hospitalization of the patients in moderate, severe, and critical status. Conclusion: At admission, it is recorded that in severe and critical COVID-19 patients the greater the WBC, neutrophile, NLR, fibrinogen, D-Dimer, CRP, LDH, ferritin parameters elevated, the more significant the lymphocyte, monocyte, eosinophile, and basophile (%) parameters dropped; especially, patients in more critical situations have witnessed a consecutively prolonged PT and increased INR.
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Keywords
COVID-19, SARS-CoV2, hematology, complete blood cell, peripheral blood cells, coagulation tests, inflammatory markers
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