Article Sidebar
Views PDF: 232
INVESTIGATING THE CHARACTERISTICS OF SEVERAL PARAMETERS LIKE PERIPHERAL BLOOD CELLS, COAGULATION TESTS AND INFLAMMATORY MARKERS IN COVID-19 PATIENTS AT CAN THO CENTRAL GENERAL HOSPITAL
Main Article Content
Abstract
Background: Being infected with SARS-CoV-2 stimulates the immune responses, alternates the quantity and morphology of blood cells or even disorders in coagulation tests and inflammatory markers. Nevertheless, the functions of these parameters in classifying COVID-19 degrees of illness have been vague. Therefore, this study is operated to initially evaluate the classific capability of the abovementioned parameters in COVID-19 patients at hospital admission. Objective: To define the characteristics of several parameters like peripheral blood cells, coagulation tests and inflammatory markers in COVID-19 patients at admission to the hospital. Material and method: retrospective study was achieved on 269 COVID-19 patients over 18 years old, who were positive with SARS-CoV-2 virus confirmed by RT-PCR assay. This study was classified into 3 categories (according to the criteria published by the Ministry of Health): moderate, severe, and critical measure at Can Tho Central General Hospital from January 2021 to March 2022. Results: The average age of the study participants is 62,7 years old. Among common comorbidities, 61,7% are hypertension (n=139), followed by 42% diabetes (n=113); 20,4% chronic kidney diseases (n=55); 19,7% cardiovascular diseases (n=53). The statistical variation (p<0,05) is represented in parameters such as WBC, neutrophile (x109/L), neutrophile (%), lymphocyte (x109/L), lymphocyte (%), monocyte (x109/L), monocyte (%), eosinophile (x109/L), eosinophile (%), basophile (%), NLR, PT, INR, fibrinogen, D-Dimer, CRP, LDH, ferritin at hospitalization of the patients in moderate, severe, and critical status. Conclusion: At admission, it is recorded that in severe and critical COVID-19 patients the greater the WBC, neutrophile, NLR, fibrinogen, D-Dimer, CRP, LDH, ferritin parameters elevated, the more significant the lymphocyte, monocyte, eosinophile, and basophile (%) parameters dropped; especially, patients in more critical situations have witnessed a consecutively prolonged PT and increased INR.
Article Details
Keywords
COVID-19, SARS-CoV2, hematology, complete blood cell, peripheral blood cells, coagulation tests, inflammatory markers
References
2. Izcovich A, Ragusa MA, Tortosa F et al (2020) Prognostic factors for severity and mortality in patients infected with COVID-19: a systematic review. PLoS ONE 15:e0241955–e0241955.
3. Liao Danying, Zhou Fen, Luo Lili, et al. (2020), "Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study", The Lancet Haematology, 7(9), pp. e671-e678.
4. Linssen, J. et al. (2020) ‘A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study.’, eLife, 9. doi: 10.7554/eLife.63195.
5. Luo, L. et al. (2020) ‘Early coagulation tests predict risk stratification and prognosis of COVID- 19.’, Aging, 12(16), pp. 15918–15937. doi: 10.18632/aging.103581.
6. Ripa, M. et al. (2021) ‘Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors.’, Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 27(3), pp. 451–457.
7. Wu, C. et al. (2020) ‘Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China.’, JAMA internal medicine, 180(7), pp. 934–943.
8. Zhao Y, Yu C, Ni W et al (2021) Peripheral blood inflammatory markers in predicting prognosis in patients with COVID-19. Some differences with influenza A. J Clin Lab Anal 35:e23657.