CÁC YẾU TỐ LIÊN QUAN ĐẾN BỆNH GIẢM TIỂU CẦU MIỄN DỊCH MẠN TÍNH Ở TRẺ EM TẠI BỆNH VIỆN NHI ĐỒNG 1

Abstract

Objectives: (1) Describe the clinical, subclinical characteristics of Immune thrombocytopenia (ITP) in children at Children’s Hospital 1 (2) Explore some relationship between clinical and subclinical characteristics of developing chronic ITP in children at Children’s Hospital 1. Research methodology: Descriptive study combined with rescuing. Subjects: 205 patients with ITP in Department of Dengue Hemorrhagic Fever and Hematology – Children’s Hospital 1 from 01/2019 to 01/2020. Results and conclusion: General characteristics: chronic ITP 23,4%, non-chronic ITP 76,6%. Chronic ITP (48 cases): female 62,5%, male 37,5%, female/male 1,67/1; Average age 83,6 ± 53,4 months; The disease usually has an acute onset with the average time of expression before admission is 4,9 ± 2,1 days. 100% of patients had bleeding at various degrees, most of them were skin and mucous hemorrhage accounting for 72,9%, intracerebral hemorrhage 4,2%; platelet counts (PLT) 19,7 ± 9,6 G/L, PLT at 3 weeks 20,3 ± 7,4 G/L; ANA positive 12,5%; Single nucleotide polymorphism (SNP) of IFNA17 gene 16,7%. Non-chronic ITP (157 cases): female 45,9 %, male 54,1 %, female/male 0,85/1; Average age 26,0 ± 39,5 months; The disease usually has an acute onset with the average time of expression before admission is 2,2 ± 1,1 days. 100% of patients had bleeding at various degrees, most of them were skin and mucous hemorrhage accounting for 82,8%, intracerebral hemorrhage 1,3%; platelet counts (PLT) 18,3 ± 11,7 G/L, PLT at 3 weeks 46,6 ± 24,1 G/L; ANA positive 3,8%; SNP of IFNA17 gene 84,1%. There was a positive relationship (p<0,05) between this factors and chronic ITP: older age of onset, average time of expression before admission, non-higher PLT at 3 weeks, ANA positive. There was a negative correlation (p<0,05) between SNP of IFNA17 and chronic ITP.