KẾT QUẢ GHÉP GAN ĐIỀU TRỊ UNG THƯ BIỂU MÔ TẾ BÀO GAN TRONG TIÊU CHUẨN MILAN TẠI BỆNH VIỆN VIỆT ĐỨC

Abstract

Objectives: To evaluate the results of liver transplantation in the treatment of hepatocellular carcinoma according to Milan criteria at Viet Duc hospital. Methods: Retrospective study of 22 patients with hepatocellular carcinoma in Milan criteria who performed liver transplantation at Viet Duc hospital from 1/2013 to 3/2022. Results: The mean age was 55,4 ± 8,8 (34 – 74), hepatitis B virus infection accounted for 86,4%, pre-transplant treatment with chemical hepatic artery embolization (TACE) and/or high ablation frequency (RFA) accounted for 27,3%, liver resection 31,8%, pre-transplant alpha-fetoprotein (AFP) > 200 ng/ml amounted to 13,6% of the patients. Child B and C patients accounted for 45,5% of the patients. The living-donor liver transplant and brain-death-donor was 22,7% and 77,3%, respectively. The cold ischemia time and warm ischemia time was 173,4 ± 76,6 and 68,8 ± 37,4 respectively. Hepatic artery thrombosis 0% and portal vein thrombosisi occupied 4,5%, post-transplant bleeding was 0%, and the 3-month post-transplant mortality rate was 4,5%. The overal survival rate after 1 year, 3 years and 5 years was 90.9%, 90.9% and 90.9%, respectively. Disease-free survival rate at 1 year, 3 years and 5 years was 95%, 95% and 95% respectively. Conclusions: Liver transplantation for HCC patients within Milan criteria was safely performed with low mortality rate. Overal survival rate after 5 years and disease – free survival rate was high.