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Date Published: 20/04/2023
Abstract Views: 133
Views PDF: 109
DOI: https://doi.org/10.51298/vmj.v525i1B.5111
Issue
Vol. 525 No. 1B (2023)
Section
Các bài báo
How to Cite
Phạm , T. V. A. ., Nguyễn, T. H. ., Nguyễn, T. V. T. ., & Đậu , T. D. . (2023). EFFECTS OF BANIKHA CAPSULES ON BENIGN PROSTATIC HYPERPLASIA MODEL IN EXPERIMENTAL ANIMALS. Vietnam Medical Journal, 525(1B). https://doi.org/10.51298/vmj.v525i1B.5111

EFFECTS OF BANIKHA CAPSULES ON BENIGN PROSTATIC HYPERPLASIA MODEL IN EXPERIMENTAL ANIMALS

Thị Vân Anh Phạm 1, Thị Hồng Nguyễn2, Thị Vân Trang Nguyễn2, Thùy Dương Đậu 1,
1 Hanoi medical university
2 Thien Phuc company

Main Article Content

Abstract

Banikha capsule is a combination of medicinal herbs, including Cordyceps, Yeast, Reishi and Red Ginseng. Objectives: To evaluate the effect of Banikha capsules on benign prostatic hyperplasia model in white mice. Subjects and methods: Mice were divided into 5 groups: group 1 was not castrated, injected with olive oil, and given water orally. Groups 2,3,4,5 were castrated, then injected with testoterone propionate at the dose of 10mg/kg b.w/day and given dutasterid at the dose of 2mg/kg/day respectively, Banikha capsules at 2 doses of 1.44 capsules/kg b.w/day and 4.32 capsules/kg b.w/day for 14 days. After that, mice were evaluated for prostate index and histological examination of prostate glands. Results: Banikha capsules at 2 doses of 1.44 tablets/kg/day and 4.32 tablets/kg/day tended to reduce prostate index and improved prostate histopathological images compared to the model group. Conclusion: Banikha capsules reduced benign prostatic hyperplasia in white mice.

Article Details

Keywords

Banikha capsules, prostatic hyperplasia model, testosterone, mice.

References

1. Alamoudi AJ, Alessi SA, Rizg WY et al, Cordycepin Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Modulation of AMPK and AKT Activation. Pharmaceutics, 2022, 8;14(8):1652.
2. Dhingra N, Bhagwat D., Benign prostatic hyperplasia: An overview of existing treatment, Indian J Pharmacol, 2011, 43:6–12.
3. Kok ET, Schouten BW, Bohnen AM et al, Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study, J Urol, 2009, 181: 710-716.
4. Lee JY, Kim S, Kim JH et al, Effects of red ginseng oil(KGC11o) on testosterone-propionate-induced benign prostatic hyperplasia. J Ginseng Res, 2022, 46(3):473-480.
5. McVary KT, Roehrborn CG, Avins AL et al, Update on AUA guideline on the management of benign prostatic hyperplasia, J Urol, 2011, 185: 1793-1803.
6. Mirone V, Fusco F, Verze P et al, Androgens and benign prostatic hyperplasia, Eur Urol Suppl, 2006, 5:410–7.
7. Nahata A, Dixit VK., Ganoderma lucidum is an inhibitor of testosterone-induced prostatic hyperplasia in rats, Andrologia, 2012, 44 Suppl 1:160-74.
8. YaHuang, Huaguo Chen, Xin Zhou et al, Inhibition effects of chlorogenic acid on benign prostatic hyperplasia in mice, European Journal of Pharmacology, 2017, 809, 191-195.