THE SIDE EFFECTS OF NEOSTIGMINE AND ATROPINE FOR TREATMENT OF HEADACHE AFTER SPINAL ANAESTHESIA OR EPIDURAL ANAESTHESIA IN OBSTETRICS

Đức Lam Nguyễn1,, Thị Hoài Khanh Lương 2, Minh Hồng Bùi 3
1 Hanoi medical university
2 Nghe An obstetrics and pediatrics hospital
3 Phu Tho general hospital

Main Article Content

Abstract

The objective: To evaluate some side effects of Neostigmine and Atropine for the treatment of headache after spinal or epidural anaesthesia in obstetrics. Sixty women having headache after spinal or epidural anesthesia, eligible for research, were randomly selected to receive treatment with Neostigmine 20mcg/kg + Atropine 10mcg/kg or Paracetamol 1g. The results showed that abdominal cramps, muscle twitches occurred only in the group of Neostigmine+Atropine with the rate of 33.3% (p<0.05), 13.3% (p>0.05) respectively, these side effects occurred transient and cured themselves. The heart rate of the patients in our 2 study groups at all times were within the normal range, no patients had arrhythmias.

Article Details

References

1. Guglielminotti J., Landau R., và Li G. (2019). Major Neurologic Complications Associated With Postdural Puncture Headache in Obstetrics: A Retrospective Cohort Study. Anesth Analg, 129(5), 1328–1336.
2. Ghaleb A. (2010). Postdural puncture headache. Anesthesiol Res Pract, 2010, 102967.
3. Kwak K.-H. (2017). Postdural puncture headache. Korean J Anesthesiol, 70(2), 136–143.
4. Plewa M.C. và McAllister R.K. (2021). Postdural Puncture Headache. StatPearls. StatPearls Publishing, Treasure Island (FL).
5. Abdelaal Ahmed Mahmoud A., Mansour A.Z., Yassin H.M. và cộng sự. (2018). Addition of Neostigmine and Atropine to Conventional Management of Postdural Puncture Headache: A Randomized Controlled Trial. Anesth Analg, 127(6), 1434–1439.
6. Amorim J.A., Gomes de Barros M.V., và Valença M.M. (2012). Post-dural (post-lumbar) puncture headache: risk factors and clinical features. Cephalalgia Int J Headache, 32(12), 916–923.
7. L’ubuský M., Berta E., Procházka M. và cộng sự. (2006). [Development of incidence of post-dural puncture headache in patients undergoing caesarean section in spinal anaesthesia at the Department of Obstetrics and Gynecology in Olomouc during 2003-2004]. Cas Lek Cesk, 145(3), 204–208.
8. Imarengiaye C. và Ekwere I. (2006). Postdural puncture headache: a cross-sectional study of incidence and severity in a new obstetric anaesthesia unit. Afr J Med Med Sci, 35(1), 47–51.
9. Headache Classification Subcommittee of the International Headache Society (2004). The International Classification of Headache Disorders: 2nd edition. Cephalalgia Int J Headache, 24 Suppl 1, 9–160.
10. Valle RGL, Godoy FL. Neostigmine for acute colonic pseudo-obstruction: A meta-analysis. Ann Med Surg. 2014;3(3):60-64.