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CHROMOSOME ABNORMAL BLASTOCYST RATE BY AGE GROUPS OF INFERTILE PATIENTS UNDERGOING IN VITRO FERTILIZATION TREATMENT
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Abstract
Objective: To evaluate embryonic chromosomal abnormalities by age groups of infertile patients with indications for in vitro fertilization treatment combined with preimplantation genetic testing for aneuploidy. Subjects and methods: prospective description of 661 blastocysts from 186 infertile patients with indications for in vitro fertilization combined with pre-implantation genetic testing for aneuploidies/PGT-A. Results: The proportion of normal chromosomal embryos was equal between group I (under 30 years old) and group II (30-35 years old), 51.1 and 54.1%, respectively (P(1-2)=0,613); The lowest rate has shown in the group III (>35 years old) with the rate of 35.7%, P(1-3); P(2-3) <0,05. There was no statistically significant difference in abnormal chromosomal blastocysts rate between group I and group II (P(1-2)=0,310) but increased significantly in group III at 47.2% (P(1-3); P(2-3)<0,001). The rate of chromosomal numerical abnormalities increased with advanced maternal age (p<0.05). In contrast, the rate of structural abnormalities shows the opposite trend, although the difference was insignificant (p=0.148). The rate of mosaic embryos in the three groups was 25%, 16.5%, and 17.1%, respectively (P(1-2)=0,069; P(1-3)=0,101; P(2-3)=0,843). Among the chromosomal numerical abnormality, the ratio of monosomy and trisomy was similar in the three groups (P(1-2);P(1-3); P(2-3)>0,05). Conclusion: In infertile patients with indications for IVF – PGT-A, the rate of abnormal chromosomal blastocyst increased statistically significantly when maternal age was over 35. The numerical chromosomal abnormality increased statistically with the advanced maternal age. Still, there was no significant difference in the rate of the structural chromosomal abnormal blastocyst, the ratio of the mosaic embryo, the rate of monosomy, and trisomy embryos between the study groups.
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Keywords
Abnormal chromosome, RIF (recurrent implantation failure), RPL (recurrent pregnancy loss), advanced maternal age.
References
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