KHẢO SÁT TÌNH HÌNH ĐỀ KHÁNG KHÁNG SINH CỦA CHỦNG VI KHUẨN STAPHYLOCOCCUS TẠI BỆNH VIỆN NGUYỄN TRI PHƯƠNG GIAI ĐOẠN 2019 - 2021

Abstract

Introduction: With the high level of antimicrobial resistance worldwide, the choice of antibiotic therapy to treat infections caused by Staphylococcus species has become a major challenge in clinical practice. Objective: Determine the positive culture rate of Staphylococcus species from 2019 to 2021; Describe the prevalence and the susceptibility pattern of Staphylococcus species to several antibiotics from 2019 to 2021. Subjects and methods: Data on antibiotic susceptibility of Staphylococcus species were collected retrospectively from the Hospital Laboratory between 2019 and 2021. Chi-square test was used to performing yearly comparisons of the susceptibility. Results: Over a 3-year period, 3103 Staphylococcus strains were isolated from different samples such as pus/secretion/catheter (47.1%), blood (30.0%), respiratory tract (15.4%), urine (4.5%). Staphylococcus aureus was the major species (55.1%). After 3 years, Staphylococcus spp. were still completely sensitive to vancomycin and linezolid; sensitive more than 50% to chloramphenicol (80.4%), doxycycline (93.9%), rifampicin (93.7%) and co-trimoxazole (68.0%). MRSA rate was very high (72.4%), in which, the proportion of hVISA (MIC vancomycin 1-2 µg/mL) was 14.9%. An increase in antibiotic susceptibility of Staphylococcus spp. were observed statistically significant (p < 0.05). The antibiotic susceptibility pattern of Staphylococcus spp. in clinical departments were similar to the hospital pattern, except for the Intensive Care Unit, which had a significantly lower susceptibility rate than other departments for most tested antibiotics. Conclusions: Staphylococcus spp. were sensitive to only few antibiotics. A high proportion of MRSA and hVISA shows difficulties in treating infectious diseases, especially in the Intensive Care Unit.