Article Sidebar

PDF
Date Published: 27/04/2023
Abstract Views: 230
Views PDF: 71
DOI: https://doi.org/10.51298/vmj.v525i2.5175
Issue
Vol. 525 No. 2 (2023)
Section
Các bài báo
How to Cite
Lương , Q. C. ., & Dương , V. T. . (2023). THE RESULT OF USE KETAMINE AND BENZODIAZEPINE IN TREATING FOR SEVERE ALCOHOL WITHDRAWAL SYNDROME. Vietnam Medical Journal, 525(2). https://doi.org/10.51298/vmj.v525i2.5175

THE RESULT OF USE KETAMINE AND BENZODIAZEPINE IN TREATING FOR SEVERE ALCOHOL WITHDRAWAL SYNDROME

Quốc Chính Lương 1,2,3,, Vương Trung Dương 4
1 Bach Mai hospital
2 Hanoi medical university
3 VNU Hanoi-University of Medicine and Pharmacy
4 HOSPITAL OF POST AND TELECOMMUNICATIONS

Main Article Content

Abstract

Objective: Describe the results of treatment for severe alcohol withdrawal syndrome with a combination of ketamine and diazepam at the Poison Control Center - Bach mai Hospital. Subjects and methods: Prospectively describe 25 patients diagnosed with severe alcohol withdrawal syndrome at the Poison Control Center from August 2021 to August 2022. Results: The regimen successfully controlled withdrawal syndrome in 92% of patients, 8% failed, no patient died. The CIWA-Ar score was highest on the first day and gradually decreased on the following days when implementing the regimen. The dose of ketamine of failed controlling on withdrawal syndrome group was larger than that of  successful group, mainly used on the first day of hospitalization. The highest dose of diazepam in the first day and gradually decreased in the following days. Conclusion: The combination regimen of ketamine and diazepam is effective in the treatment of patients with severe alcohol withdrawal syndrome.

Article Details

Keywords

severe alchohol withdrawal syndrome, ketamine, diazepam

References

1. Tilman Wetterling, Bernhard Weber, Markus Depfenhart et al. Development of a rating scale to predict the severity of alcohol withdrawal syndrome. Alcohol and Alcoholism. 2006; 41(6):611-615.
2. Tilman Wetterling, Bernhard Weber, Markus Depfenhart et al. Development of a rating scale to predict the severity of alcohol withdrawal syndrome. Alcohol and Alcoholism. 2006; 41(6):611-615.
3. Shah P, McDowell M, Ebisu R, Hanif T, Toerne T. Adjunctive Use of Ketamine for Benzodiazepine-Resistant Severe Alcohol Withdrawal: a Retrospective Evaluation. J Med Toxicol. 2018;14(3):229-236. doi:10.1007/ s13181-018-0662-8
4. Pizon AF, Lynch MJ, Benedict NJ, et al. Adjunct Ketamine Use in the Management of Severe Ethanol Withdrawal. Crit Care Med. 2018;46(8):e768-e771. doi:10.1097/ CCM.0000000000003204
5. Ngô Chí Hiếu, Nguyễn Thị Dụ. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và hồi sức bệnh nhân có hội chứng cai rượu.2003.
6. Phan Văn Tiếng, Phạm Công Hòa, Nguyễn Văn Bảy. Nhận xét kết quả điều trị sảng rượu bằng diazepam tại Bệnh viện Tâm thần Trung ương 2.2011.
7. Nông Thế Đoàn. Đánh giá hiệu quả lâm sàng phác đồ phối hợp diazepam và phenobarbital trong điều trị hội chứng cai rượu.2018.
8. Jeremiah J. Duby, Andrew J. Berry, Paricheh Ghayyem. Alcohol Withdrawal Syndrome in Critically Ill Patients: Protocolized vs Non-Protocolized Management. The journal of trauma and acute care surgery,. 77(6):938-943.