KHẢO SÁT MỘT SỐ TỰ KHÁNG THỂ THƯỜNG GẶP TRONG BỆNH LUPUS BAN ĐỎ HỆ THỐNG

Abstract

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects 5% to 7% of the population and is the third most common cause of death worldwide. The presence of certain antibodies against nuclear antigens (ANA), is a prominent feature and also the basis of diagnosis. Immunofluorescence (IF) is being preferred because of its ability to differentiate between multiple fluorescence depositions and to suggest the presence of autoantibodies to certain antigens involved clinically relevant. Objectives: Investigate the occurrence rate of autophagy and the relationship with common paraclinical indicators in systemic lupus erythematosus. Methods: Cross-sectional descriptive cross-sectional study. 70 patients were diagnosed with systemic lupus erythematosus at the University of Medicine and Pharmacy Hospital in Ho Chi Minh City from 03/2021 to 01/2022. Results: In 70 patients with systemic lupus erythematosus (mean age ± standard deviation, 35,57 ± 11,03), the prevalence was 90% female and 10% male. The common fluorescence deposition pattern is nuclear and homogeneous spots with the proportions of 61,4% and 12,9%, respectively. The frequency of antibody positivity is 52,17% (Anti-dsDNA); 14,13% (C1q); 8,69% (Anti-Nucleosome); 7,61% Beta2-Glycoprotein IgG; 5,43% (Anti-SSA); 4,34% (Anti-SM). In which hematological indicators, renal function, complement C3 C4 were significantly related with ANA and anti-ds DNA group. Conclusion: Autoimmune antibodies are commonly found in patients with systemic lupus erythematosus. In which, indirect immunofluorescence technique helps to suggest some common autoantibodies. The presence of autoantibodies is associated with a number of laboratory indicators