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Date Published: 27/04/2023
Abstract Views: 319
Views PDF: 147
DOI: https://doi.org/10.51298/vmj.v525i2.5255
Issue
Vol. 525 No. 2 (2023)
Section
Các bài báo
How to Cite
Phan , T. H. ., & Phan , T. P. . (2023). EVALUATING THE CHANGE OF FENO LEVELS DURING THE TREATMENT OF ASTHMA. Vietnam Medical Journal, 525(2). https://doi.org/10.51298/vmj.v525i2.5255

EVALUATING THE CHANGE OF FENO LEVELS DURING THE TREATMENT OF ASTHMA

Thị Hạnh Phan 1,, Thu Phương Phan 1,2
1 Bach Mai hospital
2 Hanoi medical university

Main Article Content

Abstract

Objective: To evaluate the change of FENO during the treatment of asthma in outpatient treatment at the Respiratory Center - Bach Mai Hospital. Methods: prospective cohort study of 70 outpatients at the chronic lung disease management clinic - Bach Mai Hospital from August 2021 to August 2022. Results: Among 70 patients participating in the study, after 3 months of treatment, the mean value of FENO decreased from 25.2 ± 18.1 to 18.6 ± 13.8, ACT increased from 16.9 ± 4, 8 to 19.2 ± 3.9. The FENO level was different between the fully controlled, partially controlled, and uncontrolled asthma groups. There is no correlation between percentage change of FEV1- FENO - ACT after 03 months. FENO is valuable in differentiating of eosinophil elevation (>300 cells/microliter), cut-off value of 10.5ppb, sensitivity 84.8%, specificity 69.2%. Conclusion: FENO was related to the level of asthma control according to the ACT questionnaire. FENO is valuable in detecting eosinophilia.

Article Details

Keywords

FENO, asthma

References

1. Dweik RA, Boggs PB, Erzurum SC, et al. An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications. Am J Respir Crit Care Med. 2011;184(5):602-615. doi:10.1164/ rccm.9120-11ST
2. wms-GINA-2018-report-V1.3-002.pdf. Accessed October 15, 2022. https://ginasthma.org/wp-content/uploads/2018/04/wms-GINA-2018-report-V1.3-002.pdf
3. Papakosta D, Latsios D, Manika K, Porpodis K, Kontakioti E, Gioulekas D. Asthma control test is correlated to FEV1 and nitric oxide in Greek asthmatic patients: influence of treatment. J Asthma. 2011;48(9):901-906. doi:10.3109/ 02770903.2011.611958
4. Yangui F, Ayari R, Abouda M, Charfi MR. The relationship between the fraction of exhaled nitric oxide and the level of asthma control. Tunis Med. 2019;97(7):891-897.
5. Kriti CY, Mohapatra AK, Manu MK, Kamath A. Comparison of fractional exhaled nitric oxide, spirometry, and Asthma Control Test, in predicting asthma exacerbations: A prospective cohort study. Lung India. 2020;37(5):394-399. doi:10.4103/lungindia.lungindia_546_19
6. Nguyễn Như Vinh và cộng sự. Giá Trị Của Nitric Oxide Hơi Thở Ra Trong Phân Bậc và Xếp Loại Mức Kiểm Soát Hen Theo GINA ở Bệnh Nhân Hen Tại Thành Phố Hồ Chí Minh. Đại học y dược thành phố Hồ Chí Minh; 2019.
7. Shirai T, Furuhashi K, Suda T, Chida K. Relationship of the asthma control test with pulmonary function and exhaled nitric oxide. Ann Allergy Asthma Immunol. 2008;101(6):608-613. doi:10.1016/S1081-1206(10)60223-2
8. Saito J, Sato S, Fukuhara A, et al. Association of asthma education with asthma control evaluated by asthma control test, FEV1, and fractional exhaled nitric oxide. J Asthma. 2013; 50(1):97-102. doi:10.3109/ 02770903.2012.741638
9. Badar A, Salem AM, Bamosa AO, Qutub HO, Gupta RK, Siddiqui IA. Association Between FeNO, Total Blood IgE, Peripheral Blood Eosinophil and Inflammatory Cytokines in Partly Controlled Asthma. J Asthma Allergy. 2020;13:533-543. doi:10.2147/JAA.S274022
10. Nakwan N, Thidarat Ruklerd T, Perkleang T, Taptawee P. The levels and correlations of FeNO, blood eosinophils and lung function in well-controlled asthma. Adv Respir Med. Published online January 31, 2022. doi:10.5603/ ARM.a2022.0015