GIÁ TRỊ MỘT SỐ CHỈ SỐ KHÔNG XÂM NHẬP TRONG SÀNG LỌC TĂNG ÁP LỰC TĨNH MẠCH CỬA Ở TRẺ EM

Abstract

Background & aims: The validation of noninvasive tests to diagnose esophageal varices is very important in children because endoscopic has some risks. We measured the ability of some noninvasive clinical prediction rule to predict the presence of esophageal varices in children. Method: A cross-sectional descriptive study in 108 pediatric patients have median age 1 year, quartile age 1-5 years, who were suspected portal hypertension symptoms (PH). Gastroesophageal endoscopy was taken as a gold standard. Results: Of the children studied, 79 had esophageal varices (75,4%). The most common symptoms in PH children were hepatomegaly (44.3%), splenomegaly (98.7%), anemia (60.8%) and thrombocytopenia (73.4%). For patients with clinically suspected PH such as splenomegaly, platelets below 120G/L, cut-off of noninvasive marker of esophageal varices can be used to predict PH such as AST/ALT ≥ 1.06; APRI ≥0.86, GUCI ≥1.37, FI ≥2.87. Conclusions: Some noninvasive markers as platelet, AST/ALT, APRI, GUCI, FI can be useful as a first line tool to identify PH patients to reduce the risk of upper endoscopies.