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Date Published: 16/05/2023
Abstract Views: 244
Views PDF: 129
DOI: https://doi.org/10.51298/vmj.v526i1A.5316
Issue
Vol. 526 No. 1A (2023)
Section
Các bài báo
How to Cite
Đỗ, H. K. ., & Nguyễn, V. T. . (2023). ANALYZING THE SURVIVAL OUTCOME AND TOXICITY OF INDUCTION CHEMOTHERAPY FOLLOWED BY CONCURRENT CHEMORADIATION IN LOCALLY ADVANCED SQUAMOUS CELL HEAD AND NECK CANCER. Vietnam Medical Journal, 526(1A). https://doi.org/10.51298/vmj.v526i1A.5316

ANALYZING THE SURVIVAL OUTCOME AND TOXICITY OF INDUCTION CHEMOTHERAPY FOLLOWED BY CONCURRENT CHEMORADIATION IN LOCALLY ADVANCED SQUAMOUS CELL HEAD AND NECK CANCER

Hùng Kiên Đỗ1,, Văn Tài Nguyễn1
1 k hospital

Main Article Content

Abstract

Objective: Analyzing survival outcome of induction TCF-regimen chemotherapy followed by concurrent chemoradiation in patients with locally advanced squamous cell head and neck cancer at K Hospital and assessing several toxicities of concurrent chemoradiation. Patients and method: Retrospective and prospective analysis of 47 patients with locally advanced squamous cell head and neck cancer who were treated with induction TCF-regimen chemotherapy followed by weekly platinum-based concurrent chemoradiotherapy at K Hospital from 01/2019 to 12/2022. Results: Median progression-free survival was 13.5 months. The 1-year and 2-year progression-free survival were 62%; and 29%, respectively. The common hematologic toxicity was neutropenia, often grades 1-2, and grades 3-4 neutropenia was observed in 4 patients. Grade 4 anemia was reported in 4.2% and grade 3 thrombocytopenia was seen in 2.1%. Non-hematologic toxicities were likely to be associated with radiotherapy, mostly grades 1-2. Grades 3 and 4 mucositis rates were 6.4% and 2.1%, respectively. Grades 3 and 4 xerostomia were observed in 4.2% and 2.1%, respectively. Conclusion: Induction TCF-regimen chemotherapy followed by concurrent chemoradiation for the treatment of locally advanced squamous cell head and neck cancer had improved progression-free survival with a controlable profile of toxicities.

Article Details

Keywords

squamous cell head and neck cancer, locally advanced, induction TCF-regimen chemotherapy

References

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