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ANALYSIS OF ENDOSCOPIC AND CLINICOPATHOLOGICAL CHARACTERISTICS OF GASTRIC CANCER IN YOUNG PATIENTS
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Abstract
Gastric cancer is more common in older patients, less observed in young patients. Aims: This study aimed at analyzing the endoscopic and clinicopathological characteristics of gastric cancer in young patients. Methods: We employed cross-sectional design with all young patients with gastric cancer in the Department of Gastroenterology and Hepatology, Bach Mai Hospital from July 2019 to July 2020. All patients were asked about clinical symptoms, and their gastroscopy images, histopathology results and CHD1 genetic mutation test results were collected. Results: Totally 30 patients were enrolled into the study with the average age of 34.93 (from 21-40 years old), female/male ratio was 1.5. There were 21 patients from 35 to 40 years old, accounting for 70%. The CDH1 genetic mutation rate was 50%, and 3/10 patients (10%) had family history of gastric cancer. The most common clinical symptoms were epigastric pain (90%), abdominal distension (66.7%), loss of appetite/flatulence/dyspepsia (40%). Of all patients, 80% had cancer lesions of infiltrative ulcer (Borrmann type II, III), one patient had diffuse gastric carcinoma. Regarding histopathology, 73.6% had gastric cancer with diffuse type, and 26.4% had intestinal-type poorly differentiated gastric cancer. Conclusions: Gastric cancer in young patients is more common in female than male, mainly with the diffuse type, and associated with family history of gastric cancer.
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Keywords
gastric cancer in young patients, clinical symptoms, gastroscopy, histopathology, CDH1 genetic mutation
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