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Date Published: 16/05/2023
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DOI: https://doi.org/10.51298/vmj.v526i1A.5331
Issue
Vol. 526 No. 1A (2023)
Section
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How to Cite
Lưu , Q. T. ., & Lê, T. N. . (2023). ASSESSMENT OF THE CLINICAL EFFICACY OF ANTIBIOTIC THERAPY USING COLISTIN NEBULIZER IN THE TREATMENT OF VENTILATOR-RELATED PNEUMONIA. Vietnam Medical Journal, 526(1A). https://doi.org/10.51298/vmj.v526i1A.5331

ASSESSMENT OF THE CLINICAL EFFICACY OF ANTIBIOTIC THERAPY USING COLISTIN NEBULIZER IN THE TREATMENT OF VENTILATOR-RELATED PNEUMONIA

Quang Thùy Lưu 1,, Thị Nguyệt Lê2
1 Viet Duc hospital
2 Anh Pon hospital

Main Article Content

Abstract

Objectives: To evaluate the clinical effectiveness of antibiotic therapy using nebulized Colistin compared with intravenous route in the treatment of ventilator-associated pneumonia caused by Gram(-) bacteria. Methods: Prospective study, clinical trial, randomized controlled group. 60 patients were divided into two groups by random drawing: Nebulized group (KD): use 2MUI colistin mixed in 10ml of sterile saline, nebulize every 6 hours for 30 minutes; Intravenous group (TM): use LD 9MUI colistin, then 2MUI mix 50ml of saline SE intravenously for 60 minutes x 6 hours/time. Collect data on clinical changes of the 2 study groups, process and compare by statistical methods. Results: The rate of patients had clinical response in group of patients using nebulized Colistin was 76.7% and the group of patients using intravenous Colistin was 70%. The rates of patients had clinical response on day 3, day 7 and day 10 of the nebulized route were 20%, 66.7% and 76.7%, respectively, with the intravenous group were 16.7%, 50% and 66.7%, respectively. The time patients had fever reduction of the nebulizer group was faster than that of the intravenous group: an average of 3 days in the KD group and 5 days in the TM group. Mortality was lower in the KD group than in the TM group (20% vs. 30%). Conclusion: Although the regimen using the Nebulized Colistin antibiotic had better clinical success than the intravenous route, the difference was not statistically significant.

Article Details

Keywords

Ventilator-associated pneumonia, Gr(-), Colistin, Nebulized, clinical efficacy

References

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