ASSESSMENT OF LEFT VENTRICULAR MASS AND FUNCTION IN HYPERTHROPHIC CARDIOMYOPATHY PATIENTS BY THREE-DIMENSIONAL ECHOCARDIOGRAPHY

Thị Thu Hoài Nguyễn1,2,, Thu Trang Đỗ3
1 Bach Mai hospital
2 VNU Hanoi-University of Medicine and Pharmacy
3 Hanoi medical university

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Abstract

Aims: To investigate left ventricular mass (LVM) and volume and function in patients with hypertrophic cardiomyopathy using three-dimensional echocardiography (3DE). Methods: From 6/2018 to 6/2021, patients diagnosed with hypertrophic cardiomyopathy were recruited into the study. All patients underwent clinical examination and 2D/3D echocardiography at the Vietnam National Heart Institute, Bach Mai hospital. LVM and LV volumes (EDV, ESV) and LVEF on 2D echocardiography and 3DE were assessed according to the 2015 American Society of Echocardiography guidelines. Results: Fourty-eight patients were included into the study: 22 men (45.8%), 26 women (54.2%), mean age 43,7 ± 22,3, 89.6% patients had S.A.M, 45.8% patients had mid-systolic aortic closure, 43,8% patients had elevated left ventricular outflow tract gradient (≥30 mmHg). 45.8% patients had diffused ventricular septal hypertrophy, 29.2% patients had mid-ventricular septal hypertrophy, 16.7% patients had concentric hypertrophy, 12,5% patients had apical hypertrophy. On 3DE, mean end-diastolic LV volume was 66,8 ± 24,7 (ml), mean end-systolic LV volume was 18,1 ± 10,7 (ml), mean LVEF was 74,07 ± 7,1 (%), mean LV mass was 189,7 ± 97,8 (gr). LV mass assessed by 3DE was significantly lower than LV mass assessed by time-motion (TM) echocardiography, p = 0.000. Conclusions: Three-dimensional echocardiography is safe and a non-invasive imaging method which is helpful in the evaluation of morphology and function and mass of left ventricle in patients with hypertrophic cardiomyopathy. 3DE-LVmass was was significantly lower than TM-LVmass, p =0.000.

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References

1. Maron B.J., Ommen S.R., Semsarian C. và cộng sự. (2014). Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 64(1), 83–99.
2. Haider A.W., Larson M.G., Benjamin E.J. và cộng sự. (1998). Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol, 32(5), 1454–1459.
3. Benjamin E.J. và Levy D. (1999). Why is left ventricular hypertrophy so predictive of morbidity and mortality?. Am J Med Sci, 317(3), 168–175.
4. Olivotto I., Maron M.S., Autore C. và cộng sự. (2008). Assessment and significance of left ventricular mass by cardiovascular magnetic resonance in hypertrophic cardiomyopathy. J Am Coll Cardiol, 52(7), 559–566.
5. Spirito P., Bellone P., Harris K.M. và cộng sự. (2000). Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy. N Engl J Med, 342(24), 1778–1785.
6. Avegliano G., Huguet M., Kuschnir P. và cộng sự. (2008). Utility of the real time 3D echocardiography for assessment of Left Ventricular Mass in patients with Hypertrophic Cardiomyopathy. Comparison with Cardiac Magnetic Resonance. E476–E476.
7. Chang S.-A., Kim H.-K., Lee S.-C. và cộng sự. (2013). Assessment of left ventricular mass in hypertrophic cardiomyopathy by real-time three-dimensional echocardiography using single-beat capture image. J Am Soc Echocardiogr, 26(4), 436–442.
8. Authors/Task Force members, Perry M. Elliott, Aris Anastasakis, Michael A. Borger, et al (2014). 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC), European Heart Journal, Volume 35, Issue 39, 14 October 2014, Pages 2733-2779.
9. Roberto M. Lang, Luigi P. Badano, Victor Mor-Avi, et al (2015). Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging, European Heart Journal - Cardiovascular Imaging, Volume 16, Issue 3, March 2015, Pages 233–271
10. Phạm Nhật Minh (2014). Đánh giá kết quả triệt đốt vách liên thất bằng cồn ở bệnh nhân bệnh cơ tim phì đại tắc nghẽn, Trường Đại học Y Hà Nội 2014.