NGHIÊN CỨU THỰC TRẠNG ĐỀ KHÁNG KHÁNG SINH CỦA VI KHUẨN GÂY NHIỄM KHUẨN Ổ BỤNG TẠI KHOA NGOẠI TỔNG HỢP BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI

Abstract

Background: Intra-abdominal infection is a common acute disease in a surgical emergency at Hanoi Medical University Hospital. The antibiotic resistance of bacteria is increasing, causing treatment failure, increasing the risk of death, and prolonging hospital stay, it is necessary to have bacterial studies to help doctors choice in empiric antibiotic use. Subjects and methods: This is a retrospective study, conducted by collecting and analyzing the medical records of patients with intra-abdominal infections, that were assigned to culture to identify bacteria hospitalized at the Department of General Surgery - Hanoi Medical University Hospital in the period from June 2022 to November 2022. Results: Biliary tract infections account for the largest proportion of intra-abdominal infections is 77,27%, a high proportion of Gram-negative bacteria with broad-spectrum β-lactamase enzymes (ESBL): Escherichia coli is 63.16%, Klebsiella spp. is 26.31%. The three main pathogenic bacteria strains in intra-abdominal infections are Escherichia coli, Klebsiella, and Enterococcus spp. Escherichia coli resistant to ampicillin/sulbactam is 91.43% and ciprofloxacin is 73.68%. Klebsiella spp. has high resistance to antibiotics such as ampicillin/sulbactam is 100%, ciprofloxacin is 77.78% and cefotaxime is 75%. Conclusion: The situation of Gram-negative ESBL bacteria in patients with intra-abdominal infections is very alarming, the level of antibiotic resistance of Gram-negative bacteria to penicillins, 3rd generation cephalosporins, and quinolones the higher.