TREATMENT RESULTS ON CYTOMEGALOVIRUS PATIENTS AT THE NATIONAL HOSPITAL FOR TROPICAL DISEASES

Kim Thư Nguyễn1,2,, Thị Kim Liên Dương 1
1 Hanoi medical university
2 National Hospital of Tropical Diseases

Main Article Content

Abstract

Objective: To describe the treatment results of  ganciclovir therapy  on Cytomegalovirus patients  at the National Hospital for Tropical Diseases. Subjects and method: Cross-sectional descriptive study on 58 patients diagnosed with CMV disease treated at the National Hospital of Tropical Diseases in 2 years from January 2020 to June 2022. Results: - The mean duration of ganciclovir treatment and hospitalization were 17,88 ± 7,29 and 31,76 ± 16 (days). - After treatment, 80,29% of patients had clinical symptoms response, and 20,41% did not respond. After antiviral therapy, the viremia eradication rate was 72,41% in blood and 72,22% in other specimens. There was no difference in the duration of treatment and clinical outcome between HIV and non-HIV patients. - Ganciclovir caused a statistically significant decrease in white blood cell and neutrophil counts after 21 days of treatment. Conclusion: Most patients with cytomegalovirus disease responded well to ganciclovir therapy, but close follow-up is required to detect and manage side effects.

Article Details

References

1. Arvin A, Campadelli-Fiume G, Mocarski E, et al., eds. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press; 2007. Accessed May 6, 2021. http://www.ncbi.nlm.nih.gov/books/NBK47376/
2. Hindawi. Clinical Features, Endoscopic Findings, and Predictive Factors for Mortality in Tissue-Invasive Gastrointestinal Cytomegalovirus Disease between Immunocompetent and Immunocompromised Patients. Accessed September 24, 2022. https:// www.hindawi.com/journals/grp/2021/8886525/
3. Yeh PJ, Wu RC, Chiu CT, et al. Cytomegalovirus Diseases of the Gastrointestinal Tract. Viruses. 2022;14(2):352. doi:10.3390/v14020352
4. Đỗ Minh Hoàng và CS, 2014. Đặc điểm lâm sàng, cận lâm sàng, đánh giá hiệu quả điều trị bệnh do CMV trên bệnh nhân HIV/ AIDS tại bệnh viện bệnh nhiệt đới trung ương 2010 -2012. Luận văn Thạc sỹ Y học, Đại học Y Hà Nội.
5. Khúc Văn Lập và CS (2000). Nghiên cứu đặc điểm lâm sàng, cận lâm sàng bệnh do Cytomegalovirus ở trẻ em tại Bệnh viện Nhi Trung ương. Luận văn thạc sỹ y học. Đại học Y Hà Nội.
6. Đoàn Thị Mai Thanh và CS, 2015. Một số đặc điểm dịch tễ, lâm sàng, cận lâm sàng, kết quả điều trị viêm phổi ở trẻ em có nhiễm Cytomegalovirus bằng thuốc kháng virus Ganciclovir. Luận án Tiến sỹ Y học, Viện vệ sinh dịch tễ Trung ương. :29.
7. Danziger-Isakov L, Mark Baillie G. Hematologic complications of anti-CMV therapy in solid organ transplant recipients. Clin Transplant. 2009; 23(3):295-304. doi:10.1111/j.1399-0012.2008.00942.x
8. Dw K, Cy L, Pj S, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr. 2003;143(1). doi:10.1016/s0022-3476 (03) 00192-6