NGHIÊN CỨU MẤT ĐOẠN AZF VÀ NỒNG ĐỘ HORMONE SINH DỤC Ở BỆNH NHÂN THIỂU TINH VÀ VÔ TINH

Abstract

AZF microdeletions on Y chromosome is an important cause of infertility in males. The relations between AZF microdeletions and reproductive hormones and clinical charateristics remain elusive. Objectives: To investigate AZF microdeletions on Y chromosome, serum levels of reproductive hormones and the relation between AZF microdeletions and clinical charateristics and hormone levels. Subjects and research methods: 161 oligozoospermia and azoospermic males, prospective, cross-sectional study. Results: AZF microdeletions were encountered in 15 patients (9.3%), in which AZFc microdeletion is the most frequent. Mean FSH, LH and testosterone levels were: 16.6 ± 7.4 IU/l; 8.9 ± 4.5 IU/l and 6 ± 2.4 ng/ml, respectively. There was no difference between patients with and without AZF microdeletions in sperm volumes, testes volumes, and FSH, LH and testosterone levels. Conclusions: AZF microdeletions were encountered in 9.3% of oligozoospermic and azoospermic males. There was no relation between AZF microdeletions and FSH, LH and testosterone levels.