MỐI LIÊN QUAN GIỮA NỒNG ĐỘ PLGF, SFLT-1 VỚI MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG VÀ CHỈ SỐ HÓA SINH Ở THAI PHỤ CÓ NGUY CƠ TIỀN SẢN GIẬT QUÝ 1 THAI KỲ

Abstract

Objectives to study the relationship between PlGF, sFlt-1 levels and sFlt-1/PlGF ratio with some clinical characteristics and biochemical indicators in pregnant women at risk of pre-eclampsia in the first trimester of pregnancy in Thai Nguyen. The study was conducted on 201 pregnant women with risk factors for preeclampsia and 200 normal pregnant women at gestational age in the first trimester of pregnancy with a gestational age of 11 weeks to 13 weeks and 6 days. Cross-sectional descriptive research method, the study results showed that the concentration of PlGF, sFlt-1, the ratio sFlt-1/PlGF were more related to age and related to systolic blood pressure, diastolic blood pressure. Levels of PlGF, sFlt-1 in pregnant women at risk of preeclampsia have little association with biochemical indices as well as some other clinical features in the first trimester of pregnancy. The concentration of PlGF, sFlt-1 and especially the ratio sFlt-1/PlGF can help in early diagnosis of pre-eclampsia before the appearance of clinical symptoms, according to the ROC curve, the area under the curve (AUC) of PlGF in pre-eclampsia screening was 0.717 with p < 0.001; of sFlt-1/PlGF in pre-eclampsia screening was 0.778 with p < 0.001, especially PLGFwith sensitivity and specificity of the ratio sFlt-1/PlGF were 79.1% and 67.5%, respectively. When considering each index, PLGF has a sensitivity of 60.1% and a specificity of up to 71.1%.