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Date Published: 24/07/2021
Abstract Views: 137
Views PDF: 200
DOI: https://doi.org/10.51298/vmj.v502i1.545
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Vol. 502 No. 1 (2021)
Section
Các bài báo
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Thanh Huyền, M. ., & Thị Thái Hoà, N. (2021). PROGNOSIS FACTORS OF ADVANCED STAGE NON-SMALL LUNG CANCER AFTER EGFR TKIs ACCQUIRED RESISTANCE. Vietnam Medical Journal, 502(1). https://doi.org/10.51298/vmj.v502i1.545

PROGNOSIS FACTORS OF ADVANCED STAGE NON-SMALL LUNG CANCER AFTER EGFR TKIs ACCQUIRED RESISTANCE

Mai Thanh Huyền, Nguyễn Thị Thái Hoà

Main Article Content

Abstract

Objective: To evaluate prognosis factors of advanced non-small cell lung cancer after accquired resistance to EGFR TKIs treated with Pemetrexed - Carboplatin regimen. Objects and methods: 46 patients with advanced non-small cell lung cancer with EGFR mutation, secondary resistance to TKIs, no or unknown T790M mutation, treatment withPemetrexed - Carboplatin. Retrospective studies with vertical follow-up. Results: PS0 has mPFS for 5 months, PS1 has mPFS for 3.5 months. mPFS in patients with brain metastasis: 3.3 months; no brain metastases: 5.6 months. mPFS for phase IIIB is 7 months, phase IV is 3 months. A TKI response over 6 months with an mPFS of 7 months, a response less than 6 months with an mPFS of 2.5 months. Conclusion: Brain metastasis, stage IV, response time to first line treatment TKI less than 6 months are prognostic factors with short progression - free survival with Pemetrexed – Carboplatin treated.

Article Details

Keywords

Lung cancer, non-small cell, secondary resistance to EGFR TKIs, chemotherapy, progression - free survival

References

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