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EXERCISE CAPACITY IN PATIENTS WITH TYPE 2-DIABETES BY TREADMILL ELECTROCARDIOGRAM EXERCISE TESTING
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Abstract
Aims: To investigate exercise capacity by treadmill electrocardiogram (ECG) exercise testing and the relationship between fasting blood glucose level and exercise capacity in in patients with type 2-diabetes. Methods: A retrospective study in 42 type 2-diabetic patients without cardiovascular disease and 42 age- and sex-matched healthy subjects who underwent treadmill exercise ECG testing from 1/2014 through 12/2018 in Vietnam National Heart Institute (VNHI), Bach Mai hospital. Exercise testing was performed using modified Bruce protocol. Results: In 42 patients with type 2-diabetes, mean age was 57 ± 21 (36-78 years old), 28 men (66,7%), 14 women (33,3%). In comparison with control subjects, diabetic patients had higher resting heart rate (84,2±16,7 vs 71,3±12,5 bpm, p<0,05), larger waist circumference (93,4 ±10,2 vs 81,3 ± 9,7 cm, p<0,05), higher body mass index (25,6 ± 2,1 vs 20,5 ± 1,2 kg/m2, p<0,05), higher prevalence of dyslipidemia (66,7% vs 26,2%, p<0,01), higher prevalence of family history of coronary artery disease (11,9% vs 2,4%, p<0,05), higher level of fasting blood glucose (8,8 ± 2,3 vs 4,7 ± 1,2, p<0,05). Diabetic patients had shorter exercise duration (612,4 ± 187,1 vs 813,4 ± 213,2s, p<0,01), smaller proportion of achievement of 85% theoretical maximum heart rate (76,2% vs 95,2%, p<0,01), had lower exercise functional capacity by MET (6,5 ± 1,1 vs 8,9 ± 2,7, p<0,05), lower oxygen consumption (VO2max) (31,5 ± 10,1 so với 45,2 ± 11,3 ml/kg/ph, p<0,01), higher prevalence of chronotropic incompetence (23,8% vs 4,8%, p<0,01). In diabetes, fasting blood glucose level correlated inversely and moderately with exercise duration (r = -0,49, p = 0,02), exercise functional capacity (r = -0,52, p = 0,03) and VO2max (r = -0,55, p = 0,02). Conclusions: Type 2 diabetic patients had impaired exercise capacity in comparison with non-diabetic subjects. In diabetes, fasting blood glucose level correlated inversely and moderately with exercise duration exercise functional capacity and VO2max.
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Keywords
Type 2 diabetes, exercise testing, exercise functional capacity, VO2max
References
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