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STUDY ON PREPARATION OF VERAPAMIL HYDROCLORID CORE TO IMPROVE TREATMENT EFFICIENCY ON HYPERTENSION
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Abstract
Objective: Developing the formula and preparation process of Verapamil hydrocloride pellet core. Methods: The pellet core were prepared by extrusion spheronization method; Criteria including efficiency, physical apparence and pellet core characteristics, apparent density, flow rate, abrasion, moisture content, content of active ingredient, ratio of 0.8-1.2mm pellet, solubility were evaluated. Results: Verapamil hydrocloride pellet core have been formulated with ingredients: verapamil hydrocloride 40%, Avicel PH102 45%, Lactose 12.5%, Talc 2.5%, HPMC E6 0.2g and 50mL purified water. Conclusion: The prepared pellet core of Verapamil hydrochloride meet the standards of: apperance, apparent density, flow rate, abrasion, moiture content, ratio of 0.8-1.2mm pellet and solubility
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Keywords
Verapamil hydrocloride, extrusion spheronization method
References
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