THE RESULT OF INTENSIVE BLOOD PRESSURE LOWERING IN PATIENT WITH ACUTE DEEP GREY MATTER HEMORRHAGE DUE TO HYPERTENSION

Hồng Khôi Võ 1,2,3,, Hữu Quý Hà 1,3, Thanh Thùy Hồ 2
1 Bach Mai hospital
2 Hanoi medical university
3 VNU Hanoi-University of Medicine and Pharmacy

Main Article Content

Abstract

Objectives: To assess the outcome of intensive blood pressure lowering in patient with acute deep grey matter hemorrhage. Subjects and methods: This prospective, cross-ectional descriptive study enrolled 152 patients with acute acute deep grey matter hemorrhage due to hypertension diagnosed and treated at the Neurology Center of Bach Mai Hospital from August 1st, 2021 to July 31st, 2022. Results: The average age of the study group was 60.41 ± 10.04. The age group > 60 years old accounted for the most (52%). The male:female ratio was 2.1:1. 82.9% of patients who received intensive blood pressure control reached the blood pressure target after 2 hours. Comparing computed tomography imaging between two scans, the proportion of increase in hematoma volume was only 9.2%. The percentage of patients with good outcome (mRs 0-3 points) after 7 days was 41.4%, after 28 days was 53.5%, after 90 days was 74.3%. Conclusion: The mean age of the study group was 60.41 ± 10.04 The male:female ratio was 2.1:1. Intensive blood pressure lowering contributes to early control of blood pressure according to the goal, restricting increase in hematoma volume and improving functional outcome at day 90. 

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References

1. Falcone GJ, Biffi A, Devan WJ, et al. Burden of risk alleles for hypertension increases risk of intracerebral hemorrhage. Stroke. 2012;43(11):2877-2883. doi:10.1161/STROKEAHA.112.659755
2. Broderick J, Connolly S, Feldmann E, et al. Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Circulation.2007; 116 (16): e391-413. doi: 10.1161 / CIRCULATIONAHA. 107. 183689.
3. Anderson CS, Heeley E, Huang Y, et al. Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage. New England Journal of Medicine. 2013;368(25):2355-2365. doi: 10.1056/NEJMoa1214609.
4. Nguyễn Duy Mạnh. Nghiên cứu kết quả điều trị hạ huyết áp tích cực trong chảy máu não nguyên phát do tăng huyết áp giai đoạn cấp. Luận án Tiến sĩ Y học, Viện Nghiên cứu khoa học Y Dược lâm sàng 108. 2018.
5. Đỗ Văn Tài. Đánh giá hiệu quả điều trị hạ áp tích cực ở bệnh nhân xuất huyết não giai đoạn cấp. Luận án chuyên khoa cấp II, Trường Đại học Y dược Thành phố Hồ Chí Minh. 2016.
6. Nguyễn Danh Cường. Đánh giá hiệu quả kiểm soát tích cực huyết áp bằng nicardipin đường tĩnh mạch ở bệnh nhân chảy máu trong sọ giai đoạn cấp. Luận văn Thạc sỹ Y học, Trường Đại học Y Hà Nội. 2012.