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Date Published: 26/05/2023
Abstract Views: 318
Views PDF: 105
DOI: https://doi.org/10.51298/vmj.v526i1B.5482
Issue
Vol. 526 No. 1B (2023)
Section
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Nguyễn, Đăng H., Nguyễn, D. B. ., Phạm , T. N., Lâm , K. ., Nguyễn, T. B. ., Nguyễn, T. H. ., & Trần, V. L. . (2023). SOME FEATURES OF CINGULUM TRACT ON DIFFUSION TENSOR IMAGING OF VIETNAMESE ALZHEIMER PATIENT. Vietnam Medical Journal, 526(1B). https://doi.org/10.51298/vmj.v526i1B.5482

SOME FEATURES OF CINGULUM TRACT ON DIFFUSION TENSOR IMAGING OF VIETNAMESE ALZHEIMER PATIENT

Đăng Hải Nguyễn1,, Duy Bắc Nguyễn2, Thành Nghiên Phạm 3, Khánh Lâm 4, Thanh Bình Nguyễn5, Trong Hưng Nguyễn5, Viết Lực Trần5
1 103 Military Hospital
2 Vietnam Military Medical Academy
3 Hai Phong University Of Medicine And Pharmacy
4 108 Military Central Hospital
5 National Geriatric Hospital

Main Article Content

Abstract

Objective: To reconstruct Cingulum tract (CGT) in Vietnamese Alzheimer patients (AD) by using Diffusion tensor imaging (DTI). Subject and method: Cross-sectional study. We reconstructed the white matter (WH) fibers of CGT of 20 Vietnamese Alzheimer patients and 20 normal subjects (NS) by using DTI. Result: The mean (± SD) age of AD patient and NS was: 69,05±7,77 years and 69,70±5,83 years (no significant difference, p=0,76); the age of AD onset was: 64,65±7,18 years; MMSE score: 12,20±7,35; Male/female (AD/NS) was: 8/12 and 9/11. The mean (± SD) number and length of fibers, voxel, FA and ADC of the right CGT (AD and NS) were: 461,15±307,22 fibers and 268,45±132,09 fibers; 65,43±14,20 mm and 66,35±11,31 mm; 312,50±138,39 voxels and 238,25±69,27 voxels; 0,34±0,03 and 0,36±0,02; 0,76±0,10 and 0,77±0,07 (respectively). Of that, the number fibers and voxel of AD was significantly higher (p=0,01 and p=0,04, respectively), FA was significantly lower in AD (p=0,00). The length of fibers and ADC had no significant difference (p>0,05). The mean (± SD) number and length of fibers, voxel, FA and ADC of the left CGT (AD and NS) were: 506,90±287,29 fibers and 392,40±174,96 fibers; 71,91±17,58 mm and 75,57±9,64 mm; 349,55±131,10 voxels and 306,60±70,85 voxels; 0,35±0,03 and 0,39±0,02; 0,78±0,11 and 0,76±0,05 (respectively). Of that, the number and length of fibers, voxel and ADC had not significantly difference; FA of AD group had significantly lower (p=0,00). Conclusion: the result of reconstructing CGT by using DTI suggest that: microstructure changes in white matter integrity in Vietnamese AD patients. More comparative studies are needed.

Article Details

Keywords

Cingulum tract, DTI, Alzheimer disease.

References

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