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Date Published: 01/06/2023
Abstract Views: 322
Views PDF: 155
DOI: https://doi.org/10.51298/vmj.v526i2.5494
Issue
Vol. 526 No. 2 (2023)
Section
Các bài báo
How to Cite
Đỗ, H. K. ., & Nguyễn, V. T. . (2023). TREATMENT RESULT OF INDUCTION TCF-REGIMEN CHEMOTHERAPY FOLLOWED BY CONCURRENT CHEMORADIOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL HEAD AND NECK CANCER. Vietnam Medical Journal, 526(2). https://doi.org/10.51298/vmj.v526i2.5494

TREATMENT RESULT OF INDUCTION TCF-REGIMEN CHEMOTHERAPY FOLLOWED BY CONCURRENT CHEMORADIOTHERAPY IN LOCALLY ADVANCED SQUAMOUS CELL HEAD AND NECK CANCER

Hùng Kiên Đỗ1,, Văn Tài Nguyễn1
1 k hospital

Main Article Content

Abstract

Objective: Assessing treatment response of induction TCF-regimen chemotherapy followed by concurrent chemoradiotherapy in patients with locally advanced squamous cell head and neck cancer at K Hospital and describing several toxicities of TCF chemotherapy. Patients and method: Retrospective and prospective analysis of 47 patients with locally advanced squamous cell head and neck cancer who were treated with induction TCF-regimen chemotherapy followed by weekly platinum-based concurrent chemoradiotherapy at K Hospital from 01/2019 to 12/2022. Results: Overall response rate was seen in 76.6% and disease control rate was 87.2%. Common hematologic adverse events were neutropenia, accounted for 25% grade 1 and 2,1% grade 3, respectively. The common grades 3-4 non-hematologic toxic effects were diarrhea (4.2%); nausea (12.7%), and vomiting (10.6%). Conclusion: Induction TCF-regimen chemotherapy followed by concurrent chemoradiotherapy for the treatment of locally advanced squamous cell head and neck cancer had a high overall response rate with un acceptable profile of toxicities.

Article Details

Keywords

squamous cell head and neck cancer, locally advanced, induction chemotherapy, TCF

References

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