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Date Published: 01/06/2023
Abstract Views: 885
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DOI: https://doi.org/10.51298/vmj.v526i2.5495
Issue
Vol. 526 No. 2 (2023)
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Các bài báo
How to Cite
Trần, T. ., Phạm , T. Q. ., & Nguyễn, V. H. . (2023). EVALUATION OF THE EFFICACY AND SAFETY OF GEMCITABINE PLUS CISPLATIN REGIMENS IN ADVANCED PANCREATIC CANCER PATIENTS AT K HOSPITAL. Vietnam Medical Journal, 526(2). https://doi.org/10.51298/vmj.v526i2.5495

EVALUATION OF THE EFFICACY AND SAFETY OF GEMCITABINE PLUS CISPLATIN REGIMENS IN ADVANCED PANCREATIC CANCER PATIENTS AT K HOSPITAL

Thắng Trần1,, Thị Quế Phạm 1, Văn Huy Nguyễn1
1 k hospital

Main Article Content

Abstract

Objective: Evaluation of the efficacy and safety of Gemcitabine plus cisplatin regimens in advanced pancreatic cancer patients at K Hospital. Methods: This retrospective descriptive study analyzed. 32 advanced pancreatic cancer patients were treated with Gemcitabine plus cisplatin regimens. Overall response rate (ORR), overall survival (OS) and progression-free survival (PFS) were analyzed, and some factors predicting the effectiveness of chemotherapy regimens were identified. Results: From January 2020 to November 2018, 32 patients were enrolled in the trial. Response rate was 21.9%. Disease control rate was 40.7%. The median PFS and OS were 8.2 months and 10.9 months, respectively. The rate of hematologic and non-hematologic adverse effects was low, mostly grade 1 and 2 including anemia, leukopenia, Thrombocytopenia. These percentages were 78.2 %, 43.8%, 62.5%, respectively. Conclusion: First line  gemcitabine plus cisplatin regimens for advanced pancreatic cancer patients was a safe and effective modality.

Article Details

Keywords

advanced pancreatic cancer, gem-cis regimen

References

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