MỐI TƯƠNG QUAN GIỮA NỒNG ĐỘ CRP, NT – PRO BNP VỚI MỨC ĐỘ NẶNG CỦA ĐỢT CẤP Ở NGƯỜI BỆNH ĐỢT CẤP CỦA BỆNH PHỔI TẮC NGHẼN MẠN TÍNH

Abstract

Objective: To investigate the correlation between CRP, NT - Pro BNP levels with the severity of exacerbations in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD). Subjects and methods: A cross-sectional descriptive study on 115 patients diagnosed with acute exacerbation of chronic obstructive pulmonary disease treated at the Respiratory Center of Bach Mai Hospital. Results: Exacerbations of COPD were mainly male (88.7%), over 60 years old mainly accounted for 88.7%. 80.7% of the study patients smoked or smoked pipe tobacco. CRP increased highest in patients with COPD type I with 6.97±1.06 mg/dl and p = 0.026. There is no difference in correlation between CRP and pulmonary artery pressure measured on echocardiography - Doppler cardiac. The concentration of NT-ProBNP tends to increase gradually in the group of patients with high degree of obstruction. The average concentration of NT-ProBNP in the group of patients without an increase in ALP was 90.60 ± 20.07 pmol/l lower than in the group with an increase in ALP. Conclusion: CRP concentration was positively related to the severity of exacerbation according to Anthonisen with p<0.05. The concentration of NT-ProBNP was positively related to the degree of airway obstruction and ALP on echocardiography with p<0.05.