Article Sidebar

PDF
Date Published: 01/06/2023
Abstract Views: 298
Views PDF: 147
DOI: https://doi.org/10.51298/vmj.v526i2.5525
Issue
Vol. 526 No. 2 (2023)
Section
Các bài báo
How to Cite
Nguyễn, Đức H., Bùi , T. A. ., Ngô , T. M. P. ., Tạ , V. T. ., & Nguyễn, T. M. P. . (2023). THE RELATIONSHIP BETWEEN PLASMA BETA-2-MICROGLOBULIN CONCENTRATION AND THE DEGREE OF CORONARY ARTERY STENOSIS IN PATIENTS WITH CORONARY ARTERY DISEASE. Vietnam Medical Journal, 526(2). https://doi.org/10.51298/vmj.v526i2.5525

THE RELATIONSHIP BETWEEN PLASMA BETA-2-MICROGLOBULIN CONCENTRATION AND THE DEGREE OF CORONARY ARTERY STENOSIS IN PATIENTS WITH CORONARY ARTERY DISEASE

Đức Hiển Nguyễn1,, Tuấn Anh Bùi 1, Thị Mai Phương Ngô 2, Văn Thạo Tạ 3, Thị Mai Phương Nguyễn1
1 Bach Mai hospital
2 Bahc Mai hospital
3 Hanoi medical university

Main Article Content

Abstract

Introduction: The identification of new risk factors for coronary artery disease (CAD) is increasingly being studied with the aim of early detection and prevention of this dangerous disease. Plasma beta-2-microglobulin (B2M) concentration have been reported to be associated with the progression of CAD. Objectives: 1) Describe plasma B2M concentration in patients with coronary artery disease at the Cardiovascular Institute of Bach Mai Hospital; 2) Analysis of the relationship between plasma B2M concentration and the degree of coronary artery stenosis in patients with CAD. Subjects and methods: A cross-sectional descriptive study on 50 patients with a confirmed diagnosis of CAD based on the results of percutaneous coronary angiography and 50 healthy people whose plasma B2M concentration were quantified by immunoassay for turbidity on a Cobas c702 instrument from Roche Diagnostics. Results: The plasma B2M concentration in the CAD group (2.33 ± 0.47 mg/L) was higher than that in the control group (1.84 ± 0.28 mg/L) with statistical significance with (p<0.001). Plasma B2M concentration had a moderate positive correlation with the number of narrowed coronary artery (CAD) branches and the degree of coronary artery stenosis in CAD patients with correlation coefficients of 0.469 and 0.481, respectively. Conclusion: 1) The plasma B2M concentration of CAD patients was higher than that in the control group; 2) There was a positive correlation between the plasma B2M concentration and the number of narrowed coronary artery branches and the degree of coronary stenosis in patients with CAD.

Article Details

References

1. Schünemann H.J., Schünemann A.H.J., Oxman A.D. và cộng sự. (2008). Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ, 336(7653), 1106–1110.
2. World Health Organization (2018), World health statistics 2018: monitoring health for the SDGs, sustainable development goals, World Health Organization.
3. Güssow D., Rein R., Ginjaar I. và cộng sự. (1987). The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. J Immunol, 139(9), 3132–3138.
4. Xie J. và Yi Q. (2003). Beta2-microglobulin as a potential initiator of inflammatory responses. Trends Immunol, 24(5), 228–229; author reply 229-230.
5. Shinkai S., Chaves P.H.M., Fujiwara Y. và cộng sự. (2008). Beta2-microglobulin for risk stratification of total mortality in the elderly population: comparison with cystatin C and C-reactive protein. Arch Intern Med, 168(2), 200–206.
6. Lawton J.S., Tamis-Holland J.E., Bangalore S. và cộng sự. (2022). 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation, 145(3), e4–e17.
7. You L., Xie R., Hu H. và cộng sự. (2017). High levels of serum β2-microglobulin predict severity of coronary artery disease. BMC Cardiovasc Disord, 17(1), 71.
8. Nessa Z., Ferdoushi S., Khaled M.F.I. và cộng sự. (2020). Role of serum β2m in predicting severity of Coronary artery disease. University Heart Journal, 16(1), 22–27.