ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ ĐÓNG ỐNG ĐỘNG MẠCH Ở TRẺ SƠ SINH NON THÁNG TẠI BỆNH VIỆN TRẺ EM HẢI PHÒNG NĂM 2021 - 2022

Abstract

Objectives: To describe the clinical and subclinical characteristics of preterm neonates with patent ductus arteriosus (PDA) at Hai Phong Children's Hospital from January 1, 2021 to April 30, 2022 and to comment on treatment results for closing PDA of the above children with medications. Subjects and methods: a retrospective study describing a series of cases by means of convenience sampling including all eligible patients for the study. Results: Gestational age at birth of the group of children with PDA in this study mainly concentrated in the group of 28 - <34 weeks of age (77.8%), mainly in female children. Most children were admitted to the hospital before the age of 24h with birth weight £2000g. The most common clinical symptoms were a bouncing pulse, active precordium and a systolic murmur. Co-morbidities on admission were mainly endocardial disease, transient tachypnea and pneumonia. 32/72 children were prescribed medical treatment with parenteral paracetamol. In the treatment of closure of PDA with parenteral paracetamol, the indices: left atrial size, LA/Ao ratio, lung diameter and aortic diameter of the ductus arteriosus were all significantly reduced. There were 28/32 children who were treated with parenteral paracetamol for successful tube closure. The duration of oxygen support in this group of children was significantly shorter than in the group that failed to close the ductus arteriosus. Conclusion: PDA was common in infants born <34 weeks premature with low birth weight. Treatment of tube closure with parenteral paracetamol gave good results and no side effects were noted. Further studies with larger sample sizes are needed.