HIỆU QUẢ THUỐC SULPIRIDE TRONG CẢI THIỆN CHẤT LƯỢNG CUỘC SỐNG Ở BỆNH NHẬN HỘI CHỨNG RUỘT KÍCH THÍCH

Abstract

Background: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disease associated with bowel dysfunction, which can significantly impact the quality of life (QoL) of patients. Objectives: To investigate the effect of sulpiride in improving quality in patients with IBS by ROME III criteria at University Medical Center. Methods: We conducted a cross-sectional study in patients diagnosed with IBS at the Gastroenterology clinic of University Medical Center from 01^st June, 2018 to 1^st February, 2019, indicated with or without sulpiride. The data of patient informations were collected, the QoL of patients was accessed based on validated Vietnamese version IBS-QoL questionnaire for all participants at the baseline. and after 8 weeks of follow-up. Results: After 8 weeks of follow-up, 246 patients completed the study, of which 120 patients used sulpiride and 126 patients did not use sulpiride, the female / male ratio was 1.4/1. After 8 weeks of follow-up, the overall IBS-QoL score and the domains of IBS-QoL in irritability, health anxiety, social response, and relationship in sulpiride group were statistically significantly higher than those in the non-sulpiride group. (p <0.001). The change in IBS-QoL score, the change in domain of discomfort, obstruction of performance, fitness, health anxiety, social reactions, and relationship in the sulpiride group were also higher than these in non-sulpiride group (p < 0.05). Conclusion: The use of sulpiride in the treatment of IBS patients improved overall QoL score, especially changes in the domain of uncomfortable characteristics, impeded performance, physical fitness, health anxiety, social reactions, relationships.