SO SÁNH KẾT QUẢ HÓA XẠ TRỊ TIỀN PHẪU BẰNG KỸ THUẬT 3D-CRT VÀ IMRT TRONG UNG THƯ TRỰC TRÀNG GIAI ĐOẠN T3-T4/N0

Abstract

Objective: Compare the results of neoadjuvant chemoradiation by 3D-CRT and IMRT techniques in rectal cancer stage T3-T4/N0. Patients and methods: Retrospective cohort study. From June 2017 to June 2020, 85 patients diagnosed with middle or low rectal cancer stage T3-T4/N0 received  neoadjuvant chemoradiation in K hospital. The patient was assessed to respond according to the “Resistance Evaluation Criteria for Solid Tumors” (RCIST), toxicity according to the anticancer drug toxicity classification criteria of the World Health Organization. World health organization common toxicity criteria.  Results: The overall response rate of the 3D-CRT and IMRT groups was 84.7% and 95% respectively, the difference was not statistically significant with p = 0.652. 93.8% of patients after neoadjuvant chemoradiation underwent radical surgery in the 3D-CRT group, corresponding to the IMRT group 95%, the difference was not statistically significant with p=0.333 The side effects of radiation therapy on the disease patients tend to be lower when treated with IMRT. Conclusions: The IMRT radiotherapy technique applied in neoadjuvant for rectal cancer stage T3-4/N0 is an effective and safe radiotherapy technique that tends to reduce toxicity than the 3D-CRT method. However, the difference is not statistically significant.